Exemplary Human Practices Projects
On this page you will find example projects on: stakeholder engagement, product assessment, ethics and philosophy, policies and practices, frameworks and tools and education, inclusivity and outreach.
Here we have listed a few exemplary past Human Practices efforts in various topic areas to demonstrate the breadth of teams’ work. We hope these examples provide useful inspiration for your own engagement with Human Practices issues; however, they should not be prescriptive. The most best Human Practices methods and focus areas for your team's project may not be like any these examples―in fact we love to see new approaches!
You can find more examples of excellent and inspiring work to build upon by checking out previous Integrated Human Practices special prize winners and nominees (here are links to the 2020 and 2019 results) and previous years’ Human Practices Hubs (here are links to the 2020 and 2019 Examples pages).
Engaging with potential users, stakeholders and other experts
Teams have often focused their Human Practices efforts on identifying local challenges that their project might help solve in coordination and/or cooperation with others. In these cases, teams often engage with potential users, stakeholders and other experts to inform their project selection, design and execution.
The 2019 Calgary team (First Runner Up, Undergrad; Winner, Best Integrated Human Practices, Undergrad) followed a human-centered design process to solve problems in the local canola oil industry. Before beginning lab work, they spoke to regulators, farmers, and manufacturers about their idea to remove chlorophyll from canola oil. They discovered that synthetic biology could impact every stage of canola production, not just oil processing. The team expanded the scope of their project and iteratively developed solutions for chlorophyll extraction, frost prediction, and seed grading. At each iteration, they re-engaged with stakeholders and technical experts to refine their design, closing the loop and producing a far better solution than they could have with a single round of feedback.
The 2018 RuiaMumbai team (Best Integrated Human Practices, Undergrad) aimed to produce bacteria that could clean stains from paan, a local delicacy. The team continually developed and strengthened their approach through consultation with many experts and stakeholders. For example, they approached paan vendors and an expert to identify and target the colour-producing ingredient in paan. They also approached concerned agencies and industry to understand product criteria preferred by potential users.
The 2019 FDR-HB Peru team (Best Integrated Human Practices, High School) exemplified an full-circle approach to Human Practices. The team met with TASA, the largest fish exporter in Peru, as a continuation of their 2018 project. They didn’t only meet with company scientists, but considered the needs of stakeholders in all parts of the fish harvesting cycle. Thinking critically about the process, the team developed a cadmium bioassay that could be used while fishers were still in their boats, ultimately saving resources throughout the fish harvest. They continually refined their project through additional meetings with TASA, and carefully documented these cycles of design and feedback.
In each of these cases, teams demonstrated great consideration and integration of stakeholder needs and concerns by documenting how/what they learned and how their project goals, design, execution and communication was changed.
Assessing impact and feasibility of potential products
Some teams have examined the impact and feasibility of developing, scaling and commercializing any real-world products resulting from their projects.
The 2018 Valencia UPV team (Grand Prize, Undergrad) did a market segmentation analysis for their accessible, easy-to-use biological printer. They then explored the Kano model methodology for gathering feedback, ranking user preferences, and adapting their design. The team carefully documented their process and results to encourage future iGEM teams to use the methodology.
The Tec-Chihuahua 2019 team (Best Supporting Entrepreneurship; Nominee for Best Integrated Human Practices) team wanted to address Verticillium wilt, a fungal disease harming local cotton crops. The team carefully delineated every part of the cotton value chain, from the fields to the textile and paper pulp industries. They interviewed large- and small-scale farmers, agricultural workers, government agents and industry experts to map out stakeholders at each link in the chain. The team consulted an impressive diversity of stakeholders, clearly documented their interviews, and showed how Human Practices methods can support entrepreneurship.
Other teams have explored issues of intellectual property (IP) related to their work. The 2017 Aalto-Helsinki team documented their entrepreneurship process, including writing a report on the results of their patent screen. Both the 2012 Stanford-Brown Team and the 2012 British Columbia Team made IP and patent guides for other iGEM teams hoping to better understand how the rights to their discoveries and inventions might be controlled and/or shared.
Developing new philosophical and ethical insights
Other teams have used philosophy and ethics to give their HP reflections more structure and to lend clarity to complex concepts (e.g. respect, responsibility, or morality). One way to do this is to apply existing ethics frameworks or principles to a project, identifying which philosophical questions emerge and—this is the tough part—devising responses or adapting the project as needed.
The 2019 Wageningen UR team (1st Runner-up, Overgrad) connected theoretical concepts in ethics to critical considerations for their project, ultimately acknowledging that their bacteriophage therapy could not be developed as a solution to agriculture pathogens without changes to its design. Using creative tools, the team worked with ethicists to break down the many applicable areas of ethics, and researched how ethical challenges are addressed and viewed in other fields, such as artificial intelligence in self-driving vehicles. In addition to integrated human practices work and attention to core issues such as biosecurity, the team's ethics investigation addressed many different concerns about their project’s impact from farm economics to overproliferation of synthetic biology technology.
Bielefeld 2017 (Best Foundational Advance Project, Overgrad) worked on expansion of the genetic code using non-canonical amino acids. They investigated the implications of their work by interviewing a broad range of experts—not only scientists but also leaders from several religions, ethicists, doctors, and philosophers. The team then wrote a report summarizing these perspectives on the risks and benefits of their project.
Technion-Israel 2017 discovered that there were very few resources available to iGEM teams wanting to address ethical issues regarding their project, and that most sources used complex language and were difficult to understand. The team consulted experts and the literature to develop an Ethics Handbook for iGEM teams. In 2018, the Groningen and Bordeaux teams made use of the handbook in their collaborative ethical evaluations of the production of bioplastics from cellulose.
Researching policies and practices
Many teams have done additional research into institutional, local, national, and international policies and practices related to their projects.
Some teams work directly with regulators. For example, EPFL 2019 (Grand Prize, Overgrad) identified the regulatory chain behind crop disease reporting and diagnosis, narrowing their stakeholder groups to the farmers who call in suspected cases of crop disease, the “Phytosanitary Police” who inspect and report local cases, and the national testing authority who confirm those cases. During their project, EPFL sought the input from and were educated in the procedures of each of these stakeholders, even field testing their device while under supervision from the phytosanitary police.
The SCUT FSE 2017 team collaborated with NPU China 2017 to analyze biosafety laws, regulations and practices in industrial settings across China, the EU and the US. The teams also analyzed the safety concerns identified by 2016 iGEM gold medal winners. SCUT FSE summarized their research and findings in a report, which they then included on their wiki.
The Manchester 2017 team collaborated with the UChile 2017 team and others to conduct an analysis of GMO regulations in Chile, Brazil, USA, EU, Australia, Japan, Indonesia, Korea, India and Canada. (The Manchester team used this research to explore where would be best to develop their phosphorus removal method for wastewater treatment plants, ultimately deciding on Canada.)
Designing (or documenting) Human Practices frameworks and tools
Many teams have developed and adapted frameworks and tools that might help other iGEMers and researchers respond to Human Practices issues that arise in their work.
Over many years, the Exeter team has shown how responsible research and innovation (RRI) frameworks developed outside of iGEM can guide excellent Human Practices work. The 2017 team, investigating bioremediation of local mining pollution, used the AREA framework (Anticipate, Reflect, Engage, Act) to contextualize their conversations with stakeholders. The 2018 team chose a project focused on Martian colonization, which had fewer direct stakeholders, so they instead followed an ELSA framework (Ethical, Legal and Social Approaches). The 2019 team (Best Integrated Human Practices, Overgrad) was a more multidisciplinary group, and so combined the AREA framework with the Engineering Design Process (EDP) cycle more familiar to the engineers and physicists on the team; that year, the team even wrote a paper based on their exploration of RRI methods.
The Heidelberg 2017 team (2nd Runner Up, Undergrad; Best Integrated Human Practices, Undergrad) identified and addressed safety and security concerns presented by the methods of directed evolution they were using. Heidelberg not only recognized and flagged safety issues associated with their project but also went further, developing a software tool that would address both their own project’s safety challenges and those of related research. In consultation with experts in data processing and data safety, the Heidelberg team built software to scan input sequences for potential hazards. They then made their screening tool available on their team wiki so that other research teams could use and adapt it.
Education, inclusivity, and outreach: important work that is not usually Human Practices
Many iGEM teams have done inspiring work in public education, inclusivity, and outreach. While an important contribution to synthetic biology in general, this work does not typically lead to an interchange of ideas between the team’s synthetic biology project and society, and is thus not usually considered Human Practices.
There are exceptions to this rule. Public engagement work may lead a team to encounter new issues related to whether their project is responsible and good for the world, and responding to those issues would be considered Human Practices. For example, the 2018 Marburg team (Grand Prize, Overgrad) engaged with visually-impaired high school students, learning how many scientific concepts were expressed in an inaccessible way. As a result of this engagement, they adapted their project wiki and presentation to meet strict accessibility standards.
You can read more about the difference between Integrated Human Practices and Education in the Frequently Asked Questions.