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Obesity has always been a threat to human health. It is estimated that 12.5% of people in the world suffer from obesity.

Studies have shown that obesity can aggravate anxiety while depression and anxiety also fuel obesity. It is called the "depression-obesity circle”.

How about bacteria that can consume fatty acid and generate antidepressants?

Our engineering bacteria are expected to synthesize GABA and 5-HTP from fatty acids and glycerol, which serves the purpose of energy transfer. It may break this circle and alleviate people’s “body shame”.

Then, we use E.coli Nissle 1917 as a chassis with enhanced capacity of β-oxidation of fatty acid, thereby increasing fatty acids consumption from diets to facilitate weight loss, and synthesize GABA and 5-HTP to make us get rid of depression.

To sum up, BUCT hopes to realize a therapy which can treat obesity and make the world happier.

Promotion Video

The whole BUCT team would like to thank our sponsors. Especially:

                               

Tel: 86+18718806286

Address: No.15 North Third Ring East Road,Chaoyang District,Beijing,P.R.China. Beijing University of Chemical Technology

BUCT--iGEM

BUCT--iGEM