Difference between revisions of "Team:GreatBay SCIE/Model"

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<body><h1 id='maximum-drug-loading-amount'>Maximum Drug Loading Amount</h1>
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<body><h1 id='maximum-drug-loading-amount'>Overview</h1>
 
<p>Because the doxorubicin is loaded onto the liposomes via diffusion, it must follow the pattern of the Fick&#39;s First Law, which is :</p>
 
<p>Because the doxorubicin is loaded onto the liposomes via diffusion, it must follow the pattern of the Fick&#39;s First Law, which is :</p>
 
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Revision as of 07:55, 2 October 2021

<!DOCTYPE html> Maximum Drug Loading Amount(Markdown)

Overview

Because the doxorubicin is loaded onto the liposomes via diffusion, it must follow the pattern of the Fick's First Law, which is :

In this formula, J represents the diffusion flux, D represents the diffusion coefficient, ▽ represents the gradient operator and C represents the concentration. We can work out the value of J and ▽C by carrying out experiments, which can help us work out the value of D. Which is:

And the D value can be used in the Fick's Second Law, and because the diffusion is taken place on liposome which can be considered as a perfect sphere, the formula can be inferred as is:

And through this formula, we can work out the relationship between the concentration of the doxorubicin, change in time and the change in position. Through which, we can indicate the maximum drug loading amount by the maximum concentration of doxorubicin in the liposome.