Team:NCTU Formosa/Design
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Biobrick design
With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large amount of bacteria which cause tooth decay and periodontal disease. When the amount of bacteria decrease, it will activate BMP2 and STATH to repair gums and help tooth remineralization. This mechanism can avoid the formation of biofilm during the remineralization process, and it also can achieve the best efficient restoration on the condition of fewer bacteria.
Reference
- Mounika Basavaraju, Vidya SagarSisnity et al.(2016)”Quorum quenching: Signal jamming in dental plaque biofilms”Journal of dental sciences 11(4):349-352