This year, we discovered and built up new methods and resources for future iGEMers to utilize.
- New 3D model for dental bone design.
- Discover new material making dental bone.
- Construct a new model design to simulate the dog's oral condition.
- New research description for LL-37 antimicrobial peptide.
New 3D model for dental bone design
The Structure is vital to our dental bone design, which will determine the user experience and the efficiency of using our dental bone.
Our two main goals of this mold are to optimize the efficiency of using the dental bone and make it user-friendly at the same time. To achieve our goal, we design to make the dental bone in two main structures. The comb-like part and the elliptical cylinder part. The comb-like shape is to increases the contacting area, which can improve the efficiency of using our dental bone. The elliptical cylinder structure is made as a grip for the owner to hold the dental bone tightly when the dog is chewing on the comb-like structure.
We recommend the owner hold on to the elliptical cylinder structure when feeding the dental bone. This will help the dogs' teeth rub more with the dental bone and increase the cleaning effect. After the dog eats up the comb-like structure, the owner can unloose the grip and let the dog consume the elliptical cylinder part happily.
This structure is designed and constructed by ourselves. To help future iGEMers who need this mold achieve their goal more efficiently, we put our 3D model below. Feel free to download it if you need it and print out your own mold!
Further more, with sufficient modeling skills, this 3D model can be freely adjusted. Users can modify the height, length, and other parameters of the model by their requirements!
The design of our 3D model for dental bone
Download our 3D model for dental bone and do it yourself!
From here: 3D model for dental bone
Discover new material making dental bone
The ideal material of our dental bone must have the appropriate hardness that can remain the proper elastic for the dog to bite and not too hard.
Agar powder is a common food ingredient. We discover that by adjusting the concentration of agar powder and water, products of different hardness can be produced. By directly altering the hardness to test the best rate of agar powder and water, we unearthed that the best ratio of dental bone-making material is 60ml of water and 4g of agar powder to make a DenTeeth-bone in our project.
This discover not only can be used in dental-bone making, for future iGEMers who need to use a substance with sufficient elastic and hardness, our discovery will also be helpful.
Construct a new model design to simulate the dog's oral condition
After discussing with Prof. Pin Chen, we understand the threat of eating too much dental bone. Furthermore, the oral environment in different dogs fits different conditions. Here comes a problem, how to get the best feeding interval for each dog to optimize the efficiency of our designed dental bone?
After several discussions and meetings, we finally came up with an idea: how about using reinforcement learning (RL) to customized predict the feeding intervals of any kind of dog?
RL is a subclass of machine learning concerned with how intelligent agents ought to take actions in an environment in order to maximize the notion of cumulative reward.
Through the interaction between the agent and the environment, we could find the best policy. Indeed, the model could not only apply to the periodontal disease of dogs but also could extend to any creature. In the future, iGEMers can easily optimize their product by utilizing our model because the model isn't restricted by the environment.
The design of our 3D model for dental bone
Download our GitHub code and do it yourself!
From here: Dog's oral condition model
Improve iGEM09_Slovenia Part: LL-37.
Since team iGEM09_Slovenia hasn't provided any details of the LL-37 antimicrobial peptide, we decided to put the information we've unearthed from our research and experiment process on the description page of this part.
The information we provide includes the evidence that this antimicrobial peptide can be transformed and express and the functional test of LL-37.
Our research results show that the LL-37 antimicrobial peptide can be accurately expressed and have the ability to inhibit the growth of bacteria.
We prove that the LL-37 antimicrobial peptide is a usable part for future iGEMers to develop and research, providing them a new choice of antimicrobial peptide.
Part wiki: BBa_K245114 LL-37, BBa_K245114 LL-37 experience.