Difference between revisions of "Team:NCTU Formosa/Design"

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                 <h1 class="topic" id="topic1">Biobrick design</h1>
 
                 <h1 class="topic" id="topic1">Biobrick design</h1>
 
                 <h2 class="subtopic">Overview</h2>
 
                 <h2 class="subtopic">Overview</h2>
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                <h3 class="subtopic">Model</h3>
 
  
 
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                     &#8195;&#8195;With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large amount of bacteria which cause tooth decay and periodontal disease. When the amount of bacteria decrease, it will activate BMP2 and STATH to repair gums and help tooth remineralization. This mechanism can avoid the formation of biofilm during the remineralization process, and it also can achieve the best efficient restoration on the condition of fewer bacteria.
 
                     &#8195;&#8195;With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large amount of bacteria which cause tooth decay and periodontal disease. When the amount of bacteria decrease, it will activate BMP2 and STATH to repair gums and help tooth remineralization. This mechanism can avoid the formation of biofilm during the remineralization process, and it also can achieve the best efficient restoration on the condition of fewer bacteria.
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                    &#8195;&#8195;Since the dental bone is a consumable product and eating too many dental bones might have some negative impacts on the dog's health, we have to calculate the best frequency of using DenTeeth-bone.<br>
 
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                    &#8195;&#8195;However, because the oral environment in different dogs fit different conditions, it will be difficult to figure out the best frequency of using dental bones for different dogs.<br>
 
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                    &#8195;&#8195;To achieve the goal, we constructed the reinforcement learning model. The goal of the model is to use the least dental bones to achieve the best effect of sterilization. <br>
 
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                    &#8195;&#8195;The model will calculate the best frequency of feeding and tell the user when should they feed DenTeeth-bone. By this model, the dental bones we produce can be successfully applied to all types of dogs.<br>
 
 
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Revision as of 16:23, 19 October 2021


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Biobrick design

Overview

  With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large amount of bacteria which cause tooth decay and periodontal disease. When the amount of bacteria decrease, it will activate BMP2 and STATH to repair gums and help tooth remineralization. This mechanism can avoid the formation of biofilm during the remineralization process, and it also can achieve the best efficient restoration on the condition of fewer bacteria.

Reference

  1. Mounika Basavaraju, Vidya SagarSisnity et al.(2016)”Quorum quenching: Signal jamming in dental plaque biofilms”Journal of dental sciences 11(4):349-352
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