Difference between revisions of "Team:NCKU Tainan/Entrepreneurship"
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Revision as of 04:32, 17 October 2021
Overview
This year, iGEM NCKU Tainan is focusing on therapeutics. Our Oh My Gut project aims to tackle a problem which is still unknown to many people. We are using synthetic biology to create a comprehensive solution to solve the problem of p-Cresol accumulation in CKD patients, to reduce the risks of getting cardiovascular diseases or other serious complications and help them achieve a better quality of life. We wanted to realize our project from the laboratory and apply it in the real market. Oh My Gut provides solutions to improve the quality of lives of people by setting up an affordable healthcare platform to increase the accessibility to anyone who requires medical advice, attention and products.
To bring our vision and mission into reality, engaging with our customers and stakeholders is crucial. We started with mapping out our target users, which are CKD patients and stakeholders. At first, we proposed that our engineered E. coli Nissle 1917 that possesses the ability to reduce p-Cresol accumulation can be marketed as a probiotic. However, after discussing with Taiwan Food and Drug Administration, we realized that because our product contains pharmacological effects, we need to market it as a drug. Therefore, we decided on marketing our product as a living therapeutic drug called CreSolve. Aside from a living therapeutic drug, we also designed CreSense, a medical device to help measure blood p-Cresol level using our engineered p-Cresol sensing bacteria.
We are very proud that our Oh My Gut project is able to evolve into CreSolve and CreSense which despite being two different products with different business models, all fall under one same goal. CreSolve living therapeutic drug will be directly sold to our distributors, while CreSense will be leased out to healthcare platforms and apply a recurring revenue business model to the suppliance of bacteria refills and microfluidic disc.
In order to understand how therapeutic drugs and medical devices can enter the real market, we started at the bottom, discussing the value proposition of the products and understanding customer’s needs. We subsequently conducted market and competitor research, thoughtfully devise our business model, and wrote our business plan. We aim to interpret the value of our products into a commercial business.
WHAT WE HAVE?
Mission & Vision
Assesment and evaluations of the things needed in order to potentially develop CreSense and CreSolve into a mature product.
Visualize-Design-Test
Identification and analysis of the values of CreSense and CreSolve through the help of a business model to support the viability of our products.
Product Value
A detailed plan of the strategies and processes of realizing CreSolve and CreSense’s vision and objectives.
Interview Insights
Assesment and evaluations of the things needed in order to potentially develop CreSense and CreSolve into a mature product.
FITI
Identification and analysis of the values of CreSense and CreSolve through the help of a business model to support the viability of our products.
Future
A detailed plan of the strategies and processes of realizing CreSolve and CreSense’s vision and objectives.
Mission & Vision
Our mission is to develop and distribute a novel and effective solution to combating stress-induced depression by integrating it within bubble milk tea.
Our vision is to become a focal company leading the modernized bubble industry possessing health-beneficial functional products.
Visualize-Design-Test
Business Model Canvas:
Competition Analysis
SWOT Analysis
Product Value
Interview Insights
Dr. CHEN,BO-SI 5/28
Director, Division of General Psychiatry, National Cheng Kung University Hospital
Professor, Institute of Behavioral Medicine, National Cheng Kung University
We met with Dr. Po-See Chen online to obtain further knowledge about depression. He provided us with valuable insight and information regarding the characteristics of depression and the relation of depression with the gut. We met him during the early stages of our project, and he gave us a lot of valuable advice regarding the behavior of patients, such as self-diagnosis which is very dangerous among people who suffer from depression. By conducting this meeting, we can understand more regarding the nature of depression to continue with our project. He also gave advice regarding our education activities, encouraging us to better spread awareness regarding depression, which you can find in our education page.
Professor Yu-Cheng Lin
Professor, Department of Engineering Science, National Cheng Kung University
Our first hardware idea was to detect human stress levels through saliva, we planned to extract cortisol which is the biomarker of stress, by detecting cortisol levels throughout a couple of days, we will be able to determine someone’s depression level. We made several discussions with professor Yu-Cheng Lin due to the fact that he has the real experience of extracting the different substances from saliva and detect the concentration of several substances through the paper-based electrochemical device. We wanted to continue and make this concept a reality, but suddenly covid-19 strikes Taiwan, so we were not able to go into any lab and we finally suspend the idea then search for another alternative.
Professor Chung-Hsien Wu
Professor, Department of Computer Science, National Cheng Kung University
Due to the fact that covid-19 in Taiwan escalated very quickly, we were thinking to find another way to build something even that we are not present physically. Then, we had an idea to made an artificial intelligence that can automatically detect depression using sound, and because none of our team members is from the Department of computer science we asked for guidance from Prof. Chung-Hsien Wu in developing the artificial intelligence.
Professor Chien-Hsiang Chang
Professor, Department of chemical engineering, National Cheng Kung University
Before settling with our current procedure of manufacturing Menbels, we wanted to make sure that our procedure and knowledge are sufficient for us to meet the requirements and make our system feasible to work. And professor Chien-Hsiang Chang has experience in making alginate layers to wrap several substances, Prof. Chang also ensures us that our plan is feasible and isn’t very hard to perform.
FITI
From IP to IPO Program (FITI) is a startup business competition in Taiwan on information communication, biology, medicine, science, and technology. In this competition, we were required to submit a 20-slide presentation showing the business plan for our startup. During the preparation, FITI provided an advisor, Ms. Peggy Chen, who clarified the competition's guidelines. Furthermore, through this competition, we met with our team consultant Dr. Lance Chang, the First Grand Winner of the FITI competition, and the CEO of Trade Wind Biotech. Gaining support and assistance has been especially helpful for us when conducting our business plan, especially in developing our marketing strategy.
Future
In the future, complying with Taiwan's food safety regulations will be our top priority. After our research is completed, we aim to distribute our product to be authorized by the government. Only when this step is completed will we move forward with our business plan. We have designed two areas of products for humans and pets according to our three-generation business plan. Apart from profit, we hope to build a sustainable project and provide more job opportunities in Taiwan and worldwide.
Reference
- Tsai, Ming-Hsien, et al, “Incidence, Prevalence, and Duration of Chronic Kidney Disease in Taiwan: Results from a Community-Based Screening Program of 106,094 Individuals.” Nephron, vol. 140, no. 3, 2018, pp. 175–184, www.ncbi.nlm.nih.gov/pubmed/30138926, 10.1159/000491708.
- Michishita, Ryoma, et al. “The Association between Changes in Lifestyle Behaviors and the Incidence of Chronic Kidney Disease (CKD) in Middle-Aged and Older Men.” Journal of Epidemiology, vol. 27, no. 8, Aug. 2017, pp. 389–397, 10.1016/j.je.2016.08.013.
- Jha, V, and G Garcia-Garcia. “Chronic Kidney Disease in Disadvantaged Populations.” Indian Journal of Nephrology, vol. 25, no. 2, 2015, p. 65, www.ncbi.nlm.nih.gov/pmc/articles/PMC4379627/, 10.4103/0971-4065.150078
- “1 in 10 People Worldwide Have CKD, but Many Governments Don’t Make Kidney Disease a Priority.” Healio.Com, 2018, www.healio.com/nephrology/chronic-kidney-disease/news/online/%7B7e9674fe-121f-4ec3-a62a-089b73108ffe%7D/1-in-10-people-worldwide-have-ckd-but-many-governments-dont-make-kidney-disease-a-priority.
- THE HIDDEN EPIDEMIC: WORLDWIDE, OVER 850 MILLION PEOPLE SUFFER FROM KIDNEY DISEASES. 2018.
- “KREMEZIN / COVALZIN | KUREHA CORPORATION.” Kureha.Co.Jp, 2014,