Minghan1005 (Talk | contribs) |
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, our product must be affordable, attractive, and easily accessible to increase adherence from patients and reach the ones who can’t seek medical help. We have selected bubble tea, a signature drink representing Taiwan that is low-cost and popular all around the world. This sweet delicious drink is enjoyed by all walks of life. Therefore, we can incorporate this medication into everyone’s daily life, without having to regularly take medications that must be prescribed by a doctor. How Menble works is it packages our functional E. coli Nissle 1917 which contains plasmid with our taurine-producing biobrick on it, and protects it from degradation by gastric acid in the stomach<sup>[<a href="#ref11">11</a>,<a href="#ref12">12</a>]</sup>. Its alginate composition also allows it to be digested in the intestine where the environment is basic enough, and also the combined action by acid and trypsin is able to break down its structure<sup>[<a href="#ref12">12</a>]</sup> | , our product must be affordable, attractive, and easily accessible to increase adherence from patients and reach the ones who can’t seek medical help. We have selected bubble tea, a signature drink representing Taiwan that is low-cost and popular all around the world. This sweet delicious drink is enjoyed by all walks of life. Therefore, we can incorporate this medication into everyone’s daily life, without having to regularly take medications that must be prescribed by a doctor. How Menble works is it packages our functional E. coli Nissle 1917 which contains plasmid with our taurine-producing biobrick on it, and protects it from degradation by gastric acid in the stomach<sup>[<a href="#ref11">11</a>,<a href="#ref12">12</a>]</sup>. Its alginate composition also allows it to be digested in the intestine where the environment is basic enough, and also the combined action by acid and trypsin is able to break down its structure<sup>[<a href="#ref12">12</a>]</sup> | ||
, releasing the functional bacteria into the intestine. After our bacteria produces taurine induced by the IFN-γ and oxidative stress biomarkers present in the intestine, taurine can then be transported to the brain via the gut-brain axis, making people happy again!</p> | , releasing the functional bacteria into the intestine. After our bacteria produces taurine induced by the IFN-γ and oxidative stress biomarkers present in the intestine, taurine can then be transported to the brain via the gut-brain axis, making people happy again!</p> | ||
+ | <div class="container-fluid p-0"> | ||
+ | <div class="row no-gutters"> | ||
+ | <div class="col-lg "> | ||
+ | <figure class="d-flex flex-column justify-content-center align-items-center px-lg-3"> | ||
+ | <a href="https://static.igem.org/mediawiki/2021/b/b8/T--NCKU_Tainan--menbleonthespoon.jpg" target="_blank" style="width:50%"><img src="https://static.igem.org/mediawiki/2021/b/b8/T--NCKU_Tainan--menbleonthespoon.jpg" alt="" title="" style="width:100%"></a> | ||
+ | <figcaption class="mt-3">Fig. 1. Menble bubbles</figcaption> | ||
+ | </figure> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
<h3>f(int)</h3> | <h3>f(int)</h3> | ||
<p> In order to predict how Menble will behave within our intestine, logically thinking, a human clinical trial is usually performed; nevertheless, due to animal experiments regulations and medical ethics, it is more accessible and convenient for us to perform simulation if we build an in vitro platform which can represent the human's intestine. Consequently, we decided to build <b>f(int)</b>, a microfluidic chip able to imitate the environment of a human jejunum and determine the residual rate of E. coli Nissle which stays inside the guts.</p> | <p> In order to predict how Menble will behave within our intestine, logically thinking, a human clinical trial is usually performed; nevertheless, due to animal experiments regulations and medical ethics, it is more accessible and convenient for us to perform simulation if we build an in vitro platform which can represent the human's intestine. Consequently, we decided to build <b>f(int)</b>, a microfluidic chip able to imitate the environment of a human jejunum and determine the residual rate of E. coli Nissle which stays inside the guts.</p> | ||
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<figure class="d-flex flex-column justify-content-center align-items-center px-lg-3"> | <figure class="d-flex flex-column justify-content-center align-items-center px-lg-3"> | ||
<a href="https://static.igem.org/mediawiki/2021/d/d4/T--NCKU_Tainan--microfluidics.jpg" target="_blank" style="width:50%"><img src="https://static.igem.org/mediawiki/2021/d/d4/T--NCKU_Tainan--microfluidics.jpg" alt="" title="" style="width:100%"></a> | <a href="https://static.igem.org/mediawiki/2021/d/d4/T--NCKU_Tainan--microfluidics.jpg" target="_blank" style="width:50%"><img src="https://static.igem.org/mediawiki/2021/d/d4/T--NCKU_Tainan--microfluidics.jpg" alt="" title="" style="width:100%"></a> | ||
− | <figcaption class="mt-3">Fig. | + | <figcaption class="mt-3">Fig. 2. f(int) intestinal microfluidic chip</figcaption> |
</figure> | </figure> | ||
</div> | </div> |
Revision as of 00:56, 15 October 2021