Background
Led to the caries rate skyrocketed.
Up to 3500 million people have oral problem
47% of adults aged over 30 years have some form of periodontal disease
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Processed foods are also softer and cleaner, setting up a perfect storm for caries: less chewing to | Processed foods are also softer and cleaner, setting up a perfect storm for caries: less chewing to | ||
cut the organic film and fewer dietary abrasives to wear away the nooks and crannies in teeth where | cut the organic film and fewer dietary abrasives to wear away the nooks and crannies in teeth where | ||
− | + | Plague bacteria take refuge. | |
</section> | </section> | ||
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<h2 class="topic">Dogs' oral problem</h2> | <h2 class="topic">Dogs' oral problem</h2> | ||
<section> | <section> | ||
− | Based on the research, by just three years of age, eighty percent of dogs have some form of | + | Based on the research, by just three years of age, eighty percent of dogs have some form of periodontal disease. However, the consequences of periodontal disease are not limited to the oral cavity. |
− | + | ||
</section> | </section> | ||
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<img src="https://static.igem.org/mediawiki/2021/6/6f/T--NCTU_Formosa--dogorgan.svg" class="images" id="DogOrgan" alt="DogOrgan" /> | <img src="https://static.igem.org/mediawiki/2021/6/6f/T--NCTU_Formosa--dogorgan.svg" class="images" id="DogOrgan" alt="DogOrgan" /> | ||
<section> | <section> | ||
− | The bacteria that are found within the mouth of dogs with dental disease are the same as the bacteria that result in heart disease. Additionally, the presence of | + | The bacteria that are found within the mouth of dogs with dental disease are the same as the bacteria that result in heart disease. Additionally, the presence of periodontal disease has been |
linked to the risk of heart disease in dogs. | linked to the risk of heart disease in dogs. | ||
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<p class="p4sec19">For the dental bone,while it is inexpensive, convenient, and less harmful to | <p class="p4sec19">For the dental bone,while it is inexpensive, convenient, and less harmful to | ||
dogs, it is less effective and efficient than the other methods above, due to the fact that most | dogs, it is less effective and efficient than the other methods above, due to the fact that most | ||
− | current dental bones are based on physical | + | current dental bones are based on physical friction. Only remove the bacteria and |
+ | Food residue, but add any antibacterial ingredient.</p> | ||
</section> | </section> |
Up to 3500 million people have oral problem
47% of adults aged over 30 years have some form of periodontal disease
The dogs older than three years old
Up to 80% of dogs have some form of periodontal disease
Here is the comparison of teeth brushing, teeth cleaning and dental bone. First, brushing teeth is cheap but plaque and tartar are still ineradicable. And it is also difficult for owners to brush their dogs’ teeth every day.
What about teeth cleaning?Although this is the most effective method, it costs nearly 400 US dollars, which is the most expensive method. And it needs general anesthesia to conduct. The prices and risks make some owners refuse to let their dog use it.
For the dental bone,while it is inexpensive, convenient, and less harmful to dogs, it is less effective and efficient than the other methods above, due to the fact that most current dental bones are based on physical friction. Only remove the bacteria and Food residue, but add any antibacterial ingredient.
One of our main goals is the development of a detection that is based on machine learning.Customize the period of time feeding DenTeeth and improve the effect of DenTeeth by detecting the amount of bacteria in a single dog's mouth.
In DenTeeth, antimicrobial peptides are used to sterilize.We use antimicrobial peptide LL-37, which activates autophagy and leads to cell death.
Based on previous studies, the bacteria on the teeth surface form biofilms which leads to the formation of tartar. In order to solve this problem, we introduce arginine into our project, which is able to reduce the formation of biofilms and reduce the odors as well.
Beside eliminating the main factor forming oral problems, repair of teeth and periodontal are also important.
After the amount of bacteria is below a certain value,the mechanism of repair will open, several proteins which can repair damaged gingiva or tooth tissue would be expressed.
Next, our goal is to solve the oral health problem in humans.