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+ |   Since DenTeeth is a dental bone that can switch between the sterilization and repair functions according to the concentration of bacteria. We design a quorum sensing system for it. Our E. coli with quorum sensing system can express RFP when the bacteria reach a specific concentration. While our E. coli will express GFP when the bacteria drop under this specific concentration.<br> | ||
+ |   With the Quorum Sensing Model,we can know the production of LL37 under different bacterial concentrations. Since LL37 can affect the growth of E.coli and P.gingivalis. This model can also help us complete the Growth Model. | ||
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Revision as of 07:54, 9 September 2021
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Overview
Modeling is calculating the physical phenomenon by using mathematical methods or logical algorithms. Our model aims at stimulate bacterial growth curve with DenTeeth and predicting the function of quorum sensing system. Besides, we also develop an AI which can accurately find out the best frequency for each dog using DenTeeth . Our model can be divided into the following three parts:
Growth Model
Since DenTeeth is a dental bone that can switch between the sterilization and repair functions according to the concentration of bacteria. We design a quorum sensing system for it. Our E. coli with quorum sensing system can express RFP when the bacteria reach a specific concentration. While our E. coli will express GFP when the bacteria drop under this specific concentration.
With the Quorum Sensing Model,we can know the production of LL37 under different bacterial concentrations. Since LL37 can affect the growth of E.coli and P.gingivalis. This model can also help us complete the Growth Model.
tab02的內容
tab03的內容
Assumptions of Whole Model
With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large amount of bacteria which cause tooth decay and periodontal disease. When the amount of bacteria decrease, it will activate BMP2 and STATH to repair gums and help tooth remineralization. This mechanism can avoid the formation of biofilm during the remineralization process, and it also can achieve the best efficient restoration on the condition of fewer bacteria.