<li><b>Higher serum levels of inflammatory cytokines.</b><br>Interleukin-6 (IL-6), IL-1β, and TNF-α could cause depressive disorders by disrupting neurotransmitter synthesis and signal transduction.</li>
<li><b>Higher serum levels of inflammatory cytokines.</b><br>Interleukin-6 (IL-6), IL-1β, and TNF-α could cause depressive disorders by disrupting neurotransmitter synthesis and signal transduction.</li>
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<li><b>T-cell abnormal activation.</b><br>Elevated serum levels of neopterin, as well as activation of Th1-like and Th-17-like cells, including increased production of IL-2 and IFN-γ, will activate more inflammatory cytokines production.</li>
<li><b>T-cell abnormal activation.</b><br>Elevated serum levels of neopterin, as well as activation of Th1-like and Th-17-like cells, including increased production of IL-2 and IFN-γ, will activate more inflammatory cytokines production.</li>
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<li>Chronic intestinal inflammation is strongly related to increased ROS, composed of <b>superoxide, hydrogen peroxide, and hydroxyl radical</b>, which leads to depressive symptoms through the gut-brain axis.</li>
<li>Chronic intestinal inflammation is strongly related to increased ROS, composed of <b>superoxide, hydrogen peroxide, and hydroxyl radical</b>, which leads to depressive symptoms through the gut-brain axis.</li>
</ol>
</ol>
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<p><b>  To sum up, depression is highly correlated with inflammatory response and oxidative stress. </b> However, current medication cannot effectively deal with CSID due to its difficult detection. Therefore, we try to utilize a novel synthetic biological approach to deal with this problem. After surfing previous research, <b>we found that ROS and IFN-γ are two potential biomarkers of CSID.</b> As for taurine, a kind of amino acid, it has both anti-inflammatory and ROS-scavenging effects. As a result, we use these agents to develop our project.</p>
<p><b>  To sum up, depression is highly correlated with inflammatory response and oxidative stress. </b> However, current medication cannot effectively deal with CSID due to its difficult detection. Therefore, we try to utilize a novel synthetic biological approach to deal with this problem. After surfing previous research, <b>we found that ROS and IFN-γ are two potential biomarkers of CSID.</b> As for taurine, a kind of amino acid, it has both anti-inflammatory and ROS-scavenging effects. As a result, we use these agents to develop our project.</p>