<p><b>  To sum up, depression is highly correlated with inflammatory response and oxidative stress. </b> However, current medication cannot effectively deal with CSID due to its difficult detection. Therefore, we try to utilize a novel synthetic biological approach to deal with this problem. After surfing previous research, <b>we found that ROS and IFN-γ are two potential biomarkers of CSID.</b> As for taurine, a kind of amino acid, it has both anti-inflammatory and ROS-scavenging effects. As a result, we use these agents to develop our project.</p>
<p><b>  To sum up, depression is highly correlated with inflammatory response and oxidative stress. </b> However, current medication cannot effectively deal with CSID due to its difficult detection. Therefore, we try to utilize a novel synthetic biological approach to deal with this problem. After surfing previous research, <b>we found that ROS and IFN-γ are two potential biomarkers of CSID.</b> As for taurine, a kind of amino acid, it has both anti-inflammatory and ROS-scavenging effects. As a result, we use these agents to develop our project.</p>
<h3>Taurine</h3>
<h3>Taurine</h3>
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<p>  Taurine is a semi-essential amino acid appreciated for its role in neural development and neurogenesis as a neuroprotective agent. In chronically stress-induced depressive mice models, taurine dietary has increased the L-arginine concentrations in the hypothalamus with a significant decrease in the duration of immobility in forced swimming tests.<sup>[<a href="#ref6">6</a>]</sup></p>
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<p>  Taurine is a semi-essential amino acid appreciated for its role in neural development and neurogenesis as a neuroprotective agent. In CSID mice models, taurine dietary has increased the L-arginine concentrations in the hypothalamus with a significant decrease in the duration of immobility in motility tests. Those tests indicate that taurine inflicit anxiolytic-like effect and may act as an anti-anxiety agent.<sup>[<a href="#ref6">6</a>]</sup></p>
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<p>  Moreover, studies have shown that taurine with its metabolites could significantly reduce the level of both reactive oxygen species such as HOCL and IFN-γ. Further mechanisms will be discussed in the <a href="https://2021.igem.org/Team:NCKU_Tainan/Model"><b>Model</b></a>.
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<p>  Moreover, we found out that taurine and its metabolites played a significant role in chronic intestinal inflammation, which could inhibit deterioration of CSID by gut-brain axis. Further mechanisms will be discussed in the <a href="https://2021.igem.org/Team:NCKU_Tainan/Model"><b>Model</b></a>.