Minghan1005 (Talk | contribs) |
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<p> Exposure to prolonged chronic stress induces heightened vulnerability to anxiety, depression, and several mood disorders. Chronic stress-induced depression (CSID) is characterized by the dysfunction of the medial prefrontal cortex (mPFC) in the brain, linked to cognitive and emotional deficiencies induced by long-term stress exposure<sup>[<a href="#ref2">2</a>]</sup>.</p> | <p> Exposure to prolonged chronic stress induces heightened vulnerability to anxiety, depression, and several mood disorders. Chronic stress-induced depression (CSID) is characterized by the dysfunction of the medial prefrontal cortex (mPFC) in the brain, linked to cognitive and emotional deficiencies induced by long-term stress exposure<sup>[<a href="#ref2">2</a>]</sup>.</p> | ||
<p> Research has shown that chronic stress is closely related to the dysregulation of the gut-brain axis. In addition, gut-modifying substances, such as immune-inflammatory cytokines and Reactive oxygen species (ROS), cause detrimental effects on the gute<sup>[<a href="#ref3">3</a>]</sup>. The immune-inflammatory and oxidative stress pathways will be further discussed in the following sections.</p> | <p> Research has shown that chronic stress is closely related to the dysregulation of the gut-brain axis. In addition, gut-modifying substances, such as immune-inflammatory cytokines and Reactive oxygen species (ROS), cause detrimental effects on the gute<sup>[<a href="#ref3">3</a>]</sup>. The immune-inflammatory and oxidative stress pathways will be further discussed in the following sections.</p> | ||
− | + | <div class="container-fluid p-0"> | |
+ | <div class="row no-gutters"> | ||
+ | <div class="col-lg "> | ||
+ | <figure class="d-flex flex-column justify-content-center align-items-center px-lg-3"> | ||
+ | <a href="https://static.igem.org/mediawiki/2021/c/c8/T--NCKU_Tainan--descriptionbigpicture.gif" target="_blank" style="width:50%"><img src="https://static.igem.org/mediawiki/2021/c/c8/T--NCKU_Tainan--descriptionbigpicture.gif" alt="" title="" style="width:100%"></a> | ||
+ | <figcaption class="mt-3"></figcaption> | ||
+ | </figure> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
<h3>Immune-inflammatory Pathway in Depression</h3> | <h3>Immune-inflammatory Pathway in Depression</h3> | ||
<p> <b>Interferon-gamma (IFN-γ) is known to be positively correlated with depressive symptoms<sup>[<a href="#ref4">4</a>]</sup></b>. Research indicates that the activation of immune-inflammatory pathways and neural-immune interactions are closely involved in the pathophysiology of depressive disorders.</p> | <p> <b>Interferon-gamma (IFN-γ) is known to be positively correlated with depressive symptoms<sup>[<a href="#ref4">4</a>]</sup></b>. Research indicates that the activation of immune-inflammatory pathways and neural-immune interactions are closely involved in the pathophysiology of depressive disorders.</p> |
Revision as of 14:52, 19 October 2021