<p> Menbles are bubbles containing our engineered <i>E. coli Nissle </i> which aims to alleviate chronic stress-induced depression by producing taurine when it senses a high concentration of IFN-γ and oxidative stress. As edible bubbles, Menbles are designed to be affordable and highly accessible product that can be easily incorporated into our daily lives, created to be an alternative solution for people who fear seeking medical help due to social stigma and/or low drug compliance<sup>[<a href="#ref9">9</a>,<a href="#ref10">10</a>]</sup>.
<p> Menbles are bubbles containing our engineered <i>E. coli Nissle </i> which aims to alleviate chronic stress-induced depression by producing taurine when it senses a high concentration of IFN-γ and oxidative stress. As edible bubbles, Menbles are designed to be affordable and highly accessible product that can be easily incorporated into our daily lives, created to be an alternative solution for people who fear seeking medical help due to social stigma and/or low drug compliance<sup>[<a href="#ref9">9</a>,<a href="#ref10">10</a>]</sup>.
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The main ingredient of Menbles is sodium alginate, which is able to resist degradation in environments with low pH, such as in the stomach gastric acid<sup>[<a href="#ref11">11</a>,<a href="#ref12">12</a>]</sup></p>. In environments of higher pH such as in the small intestine (pH 7.4), Menbles are able to release our engineered bacteria into its surroundings and initiate the production of taurine.</p>
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The main ingredient of Menbles is sodium alginate, which is able to resist degradation in environments with low pH, such as in the stomach gastric acid<sup>[<a href="#ref11">11</a>,<a href="#ref12">12</a>]</sup>. In environments of higher pH such as in the small intestine (pH 7.4), Menbles are able to release our engineered bacteria into its surroundings and initiate the production of taurine.</p>