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<h2 id ="Subtitle3">What is our inspiration?</h2> | <h2 id ="Subtitle3">What is our inspiration?</h2> | ||
− | <p> | + | <p> As the COVID-19 pandemic spreads across the world, fast-spreading variants have caused resurges in infections and newly-imposed lockdowns after the 2020 outbreak. Devastations of the pandemic - millions of deaths, historic economic slump and strict bans of social interactions- have already made tremendous impacts on peoples’ mental health. Yet little does the world know its severity<sup>[<a href="#ref13">13</a>]</sup>.</p> |
− | + | <p> Depressive symptom is an imperative health issue due to its comparatively high prevalence in the general population nowadays. Accompanied by prolonged social isolation, deficient psychological health, and even suicidal tendencies, depressive symptoms often take their toll on individuals’ well-being and daily functioning on the sly. Studies conducted so far also indicated that there was skyrocketing reported symptoms of anxiety, grief and depression in Taiwan after struck by the pandemic extremely this year<sup>[<a href="#ref14">14</a>]</sup>. However, due to the limited awareness of symptoms and shying away for treatments, only 20% of the depressive patients in Taiwan sought for medical support pre-pandemic occasionally, not to mention during the pandemic<sup>[<a href="#ref9">9</a>,<a href="#ref12">15</a>]</sup>.</p> | |
− | + | <p> Therefore, iGEM NCKU Tainan 2021 is dedicated to developing a novel, convenient and highly-acceptable solution targeting widespread depressive symptoms.</p> | |
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<hr> | <hr> | ||
<section class="ref"> | <section class="ref"> | ||
<h2>References</h2> | <h2>References</h2> | ||
<ol> | <ol> | ||
− | <li id="ref1"> | + | <li id="ref1">Westfall S, Caracci F, Estill M, Frolinger T, Shen L, Pasinetti GM. Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity. Frontiers in Immunology. 2021;12. doi:10.3389/fimmu.2021.670500</li> |
− | <li id="ref2"> | + | <li id="ref2">James SL, Abate D, Abate KH, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet. 2018;392(10159):1789-1858. doi:10.1016/s0140-6736(18)32279-7</li> |
− | <li id="ref3"> | + | <li id="ref3">Du Y, Gao X-R, Peng L, Ge J-F. Crosstalk between the microbiota-gut-brain axis and depression. Heliyon. 2020;6(6):e04097. doi:10.1016/j.heliyon.2020.e04097</li> |
− | <li id="ref4"> | + | <li id="ref4">Europe PMC. Europe PMC. Europepmc.org. Published 2016. Accessed October 9, 2021. <a href="http://europepmc.org/article/PMC/2740752">http://europepmc.org/article/PMC/2740752</a></li> |
− | <li id="ref5"> | + | <li id="ref5">Bhatt S, Nagappa AN, Patil CR. Role of oxidative stress in depression. Drug Discov Today. 2020;25(7):1270-1276. doi:10.1016/j.drudis.2020.05.001</li> |
− | <li id="ref6"> | + | <li id="ref6">Kong WX, Chen SW, Li YL, et al. Effects of taurine on rat behaviors in three anxiety models. Pharmacology Biochemistry and Behavior. 2006;83(2):271-276. doi:10.1016/j.pbb.2006.02.007</li> |
− | <li id="ref7"> | + | <li id="ref7">Suliman ME, Bárány P, Filho JCD, Lindholm B, Bergström J. Accumulation of taurine in patients with renal failure. Nephrology Dialysis Transplantation. 2002;17(3):528-529. doi:10.1093/ndt/17.3.52</li> |
− | <li id="ref8"> | + | <li id="ref8">van de Poll MCG, Dejong CHC, Soeters PB. Adequate Range for Sulfur-Containing Amino Acids and Biomarkers for Their Excess: Lessons from Enteral and Parenteral Nutrition. The Journal of Nutrition. 2006;136(6):1694S1700S. doi:10.1093/jn/136.6.1694s</li> |
− | <li id=" | + | <li id="ref9">Taiwan News. Only 20% of Taiwanese depression sufferers seek help: doctor | Taiwan News | 2018-05-20 14:04:00. Taiwan News. Published 2018. Accessed September 16, 2021. <a href="https://www.taiwannews.com.tw/en/news/3435488">https://www.taiwannews.com.tw/en/news/3435488</a></li> |
− | <li id=" | + | <li id="ref10">Stigma and Discrimination. Psychiatry.org. Published 2020. Accessed October 10, 2021. <a href="https://www.psychiatry.org/patients-families/stigma-and-discrimination">https://www.psychiatry.org/patients-families/stigma-and-discrimination</a></li> |
− | <li id=" | + | <li id="ref11">Chuang J-J, Huang Y-Y, Lo S-H, et al. Effects of pH on the Shape of Alginate Particles and Its Release Behavior. International Journal of Polymer Science. 2017;2017:1-9. doi:10.1155/2017/3902704</li> |
− | <li id=" | + | <li id="ref12">Guo L, Goff HD, Xu F, et al. The effect of sodium alginate on nutrient digestion and metabolic responses during both in vitro and in vivo digestion process. Food Hydrocolloids. 2020;107:105304. doi:10.1016/j.foodhyd.2019.105304</li> |
− | <li id=" | + | <li id="ref13">Abbott A. COVID’s mental-health toll: how scientists are tracking a surge in depression. Nature. 2021;590(7845):194-195. doi:10.1038/d41586-021-00175-z</li> |
− | <li id=" | + | <li id="ref14">Lu M-Y, Ahorsu DK, Kukreti S, et al. The Prevalence of Post-traumatic Stress Disorder Symptoms, Sleep Problems, and Psychological Distress Among COVID-19 Frontline Healthcare Workers in Taiwan. Frontiers in Psychiatry. 2021;12. doi:10.3389/fpsyt.2021.705657</li> |
+ | <li id="ref15">Hossain MM, Tasnim S, Sultana A, et al. Epidemiology of mental health problems in COVID-19: a review. F1000Research. 2020;9:636. doi:10.12688/f1000research.24457.1</li> | ||
<li>Flaticon, the largest database of free vector icons. (n.d.). Retrieved from <a href="https://www.flaticon.com/home">https://www.flaticon.com/home</a>.</li> | <li>Flaticon, the largest database of free vector icons. (n.d.). Retrieved from <a href="https://www.flaticon.com/home">https://www.flaticon.com/home</a>.</li> | ||
</ol> | </ol> |
Revision as of 18:59, 13 October 2021