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− |   With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large | + |   With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large number of bacteria that cause tooth decay and periodontal disease. When the number of bacteria decrease, it will activate BMP2 and STATH to repair gums and help tooth remineralization. This mechanism can avoid the formation of biofilm during the remineralization process, and it also can achieve the best efficient restoration on the condition of fewer bacteria. |
+ | </p> | ||
+ | <h1 class="topic" id="topic1">DenTeeth</h1> | ||
+ | <h1 class="subtopic" id="topic1"><i>E .coli</i> DenTeeth</h1> | ||
+ | <p id="p1"> | ||
+ |   DenTeeth is the revolution of <i>E. coli</i> BL21. Since <i>E. coli</i> BL21 is a colony that has the properties that have the high-level expression of recombinant proteins. By its high-level expression characteristics, we can test our protein function more efficiently. | ||
+ | </p> | ||
+ | <h1 class="subtopic" id="topic1">Expression conditions : under high temperature</h1> | ||
+ | <p id="p1"> | ||
+ |   DenTeeth is the revolution of <i>E. coli</i> BL21. Since <i>E. coli</i> BL21 is a colony that has the properties that have the high-level expression of recombinant proteins. By its high-level expression characteristics, we can test our protein function more efficiently. | ||
</p> | </p> | ||
Revision as of 17:14, 21 October 2021
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Overview
With quorum sensing and repressible promoter, our biobrick has a time span to achieve oral sterilization and restoration. With the increase of oral bacteria, it will activate the antimicrobial peptide LL-37 to inhibit the large number of bacteria that cause tooth decay and periodontal disease. When the number of bacteria decrease, it will activate BMP2 and STATH to repair gums and help tooth remineralization. This mechanism can avoid the formation of biofilm during the remineralization process, and it also can achieve the best efficient restoration on the condition of fewer bacteria.
DenTeeth
E .coli DenTeeth
DenTeeth is the revolution of E. coli BL21. Since E. coli BL21 is a colony that has the properties that have the high-level expression of recombinant proteins. By its high-level expression characteristics, we can test our protein function more efficiently.
Expression conditions : under high temperature
DenTeeth is the revolution of E. coli BL21. Since E. coli BL21 is a colony that has the properties that have the high-level expression of recombinant proteins. By its high-level expression characteristics, we can test our protein function more efficiently.
Reference
- Mounika Basavaraju, Vidya SagarSisnity et al.(2016)”Quorum quenching: Signal jamming in dental plaque biofilms”Journal of dental sciences 11(4):349-352