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                        <h2>Introduction</h2>
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                     <div class="col-md-4 col-lg-3 p-2 d-none d-md-block" style="background-color: #FFBD59 !important; color: #8D1063;">
                        <p>Natural systems are highly complex to understand as well as to experiment with. To make predictions of the outcomes,
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                        <div class="card" style=" max-width: 15.5rem; border: none !important;background-color:#FFBD59;" id="index">
                            we use the available information and the knowledge of physics, mathematics, chemistry, and computer science to build a theoretical model. This page deals with the models built on the different aspects of our project namely :</p>
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                             <div class="card-body">
                            <ol>
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                                 <h3 class="card-title text-center mb-3">INDEX</h3>
                                <li>GMO delivery</li>
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                                 <section id="Index1">  
                                <li>GMO growth and colonisation</li>
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                                    <ul>
                                <li>Protease production</li>
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                                        <li><a class="index_link" href="#1">Hosted Collabs</a></li>
                                <li>Diffusion and ovum Hardening</li>
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                                        <li><a class="index_link" href="#2">Individual Collabs</a></li>
                                <li>Kill switch for reversibility</li>
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                                        <li><a class="index_link" href="#3">Group Collabs</a></li>
                                <li>Kill switch for Biosafety</li>
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                                     </ul>                        
                                </ol>
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                                 </section>
                            <h2>Delivery & Colonisation</h2><br>
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                            </div>
                            <h3>INTRODUCTION: THE JOURNEY OF GMO BEGINS</h3><br>
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                          </div>
                            <h4>PART A: Delivery</h4><br>
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                            <h5>OVERVIEW</h5>
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                            <p>Delivery is an essential part of our project as it determines the audience we reach. We tried to develop multiple
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                                ways to deliver GMO in a user-friendly way with minimum invasion. Minimum invasion means it should not colonize
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                                the whole reproductive tract or reach the ovaries. The device should ensure bacterial colonization in the ampulla
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                                of the fallopian tube.
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                                One of the constraints that we faced is the high viscosity of the oviductal fluid.</p><P>
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                                After calculating the time taken for delivery in each method, talking to a couple of IVF experts, and getting their
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                                inputs into it,we thought hysteroscopic techniques would be the best for our purpose. This method gives us an advantage
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                                by delivering the bacteria directly into the ampulla region.</p>
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                            <h5>DEVICE DESIGNING (How to deliver?)</h5>
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                            <p>GMO will be delivered directly to the ampulla by a process called Hysteroscopy. It’s done with medical assistance and requires
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                                constant X-Ray monitoring to ensure the catheter is inserted without any issues. The reason is that the Ostia and the Fallopian
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                                tube are dynamic structures and that there is no chemical or significant physical difference between the ampulla and the other
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                                components of the Fallopian tube.</p>
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                            <p>A solution of GMO of a specific concentration is prepared. Then the catheter is inserted under medical guidance up to the ampulla.
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                                Then an injector is projected with narrow long incisions on both sides of it, which ensures that the GMO forms a ring along the
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                                circumference of the tube. Ovum is now
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                                360° surrounded by the GMO. </p>
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                            <p>The GMO Lactobacillus Acidophilus has pili which expectantly forms hydrogen bonds at the tube circumference with mucin found in mucus.
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                                The GMO is now adhered to the walls and multiplies once it adjusts to the introduced environment (lag phase) </p>
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                            <h5>FUTURE ASPECTS:</h5>
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                            <p>Since we aim to reach a larger population, the hysteroscopic technique, we believe, is too expensive.
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                                We also considered using hydrogels for the delivery of bacteria at a pH-specific region.</p><P>
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                                Why is this system compatible with the delivery of bacteria in the ampulla of the Fallopian tube region?</P><P>
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                                We found out that the pH in the oviductal Ampulla region is close to 8.0.
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                                That’s why we considered using hydrogels for bacterial delivery, which swells up at a pH range of 7.8 to 8.0. </P><P>
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                                Amongst the stimuli-responsive hydrogels, pH-sensitive hydrogels are the most studied hydrogels. The rate at
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                                which hydrogels respond depends upon their size, shape, cross-linking density, number of ionic groups, and composition,
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                                which can be tailored by varying these factors. The response rate increases with increasing pore size and number of ionic
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                                groups and decreasing their size and cross-linking density.</P><P>
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                                For a delivery in a basic medium, we planned to use anionic hydrogels, such as carboxymethyl chitosan, which swell at higher
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                                pH (basic medium) due to ionization of the acidic groups. As a result, the ionized negatively charged pendant groups on the
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                                polymer chains cause repulsion leading to swelling. This property of hydrogels can be exploited for GMO delivery at pH 7.4
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                                in the ampulla of the fallopian tube. </p>
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                            <h5>CELL ENCAPSULATION (What to deliver?)</h5>
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                            <p>Our goal is to design a live-bacteria entrapment system. More than just encapsulating bacteria, we want to entirely prevent
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                                their escape from the bead body into the surroundings.</p>
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                            <p>The Oviductal Fluid is slightly alkaline (ph 7.4 to 7.7), so we need our encapsulating membrane to dissolve away at this pH.
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                                Potential candidates for hydrogel materials include chitosan, guar gum, and xanthan. Chitosan forms Hydrogen bonds with the
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                                mucin protein in the mucus allowing for the anchoring at the walls and preventing the hydrogels from getting washed away.</p>
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                            <h4>PART B: Colonization</h4><br>
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                            <h5>OVERVIEW (why is it necessary to study growth and colonization)</h5>
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                            <p>In biosynthesis, growth kinetics is a crucial study to be conducted. The growth of a cell comprises both the size and the number.
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                                These growths are affected by external factors such as temperature, the chemical composition of the growth nutrient, etc., and by
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                                different physiological factors such as growth factor proteins[1][2]. The cells in a particular environment extract the nutrients
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                                from the growth media and produce biomolecules, which humans utilize for different purposes. This phenomenon has applications, from
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                                producing delicious Italian wine to getting antibiotics which saves millions of lives every year. We will be using this simple
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                                formula to reach the goals of our project. To have a qualitative understanding of the protein production by the Genetically Modified
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                                anism(GMO), we need to have a theoretical approach. We need to understand how we can calculate the growth of GMOs [3]. This, in turn,
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                                will help us figure out protein production. This detailed study of growth kinetics will help us calculate the initial inoculation
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                                required for the production of a protein that we need.</p>
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                            <p>For a better understanding, we will be considering two cases. The first comprises the study of the growth of Bacillus Subtilis in
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                                normal petri dish conditions. This is the known environment and we can have this condition easily in computer simulation and/or lab
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                                and reconfirm our model. The second case of study is the continuous culture model where we study the growth of Lactobacillus
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                                Acidophilus in the fallopian tube, which is our target region.  </p>
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                            <h6>GROWTH MODELS</h6><br>
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                            <p>PETRI DISH MODEL (Bacillus Subtilis, curve fitting)</p><br>
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                            <p>CONTINUOUS CULTURE MODEL (lactobacillus acidophilus + fallopian tube environment)</p><br>
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                            <h5>INOCULUM CALCULATIONS (connection with 2nd module)</h5><br>
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                            <h2>Protease production</h2><br>
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                            <h3>OVERVIEW ( overall picture) </h3>
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                            <p>Well known for extracellular protease production[1], Bacillus subtilis is our model organism for the proof of concept experiments. Moreover,
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                                it is a gram-positive bacteria which even if not too close but is closer than e coli (gram-negative) to our proposed bacteria lactobacillus
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                                Acidophilus. This module deals with the whole mechanism of action ideally the GMO must follow for contraception to be attained. To know how
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                            this module developed to what it is, please refer to the engineering success (hyperlink).</p>
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                            <p>Let's create the flow, you must know by now that we plan to produce the protease known as ovastacin,
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                                an indigenous protease[2] to the human ovum. It is known to cause Zona pellucida hardening naturally
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                                used by the ovum to prevent polyspermy[3]. To see the mechanism of zona pellucida hardening click here
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                                (goes to project overview where it is explained).</p>
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                            <h5> 1] Total amount of ovastacin required: </h5>
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                            <p>[We assume one active ovastacin cleaves one ZP2 glycoprotein present in the Zona pellucida matrix. To get the number of molecules of ovastacin needed, we calculated the number of ZP2 glycoproteins present on the surface of the ovum. For this, we reached out to studies that looked at the thickness of the ovum with and without the zona pellucida layer to find its overall thickness and the radius of the ovum[4]. </p>
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                            <br>
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                            <h6>Constants and calculations:</h6><br>
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                             <div class="table-responsive-md">
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                                 <table class="table">
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                                    <thead>
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                                        <tr>
+
                                          <th>Parameter (need alternative) </th>
+
                                          <th>Value</th>
+
                                          <th>References</th>
+
                                        </tr>
+
                                    </thead>
+
                                    <tbody>
+
                                        <tr>
+
                                          <td>Zona pellucida thickness</td>
+
                                          <td>18.9 μm</td>
+
                                          <td>Does zona pellucida thickness influence the fertilization rate? E. Bertrand1 , M.Van Den Bergh and Y.Englert</td>
+
                                        </tr>
+
                                        <tr>
+
                                          <td>Oocyte diameter</td>
+
                                          <td>123.5 μm</td>
+
                                          <td>Does zona pellucida thickness influence the fertilization rate? E. Bertrand1 , M.Van Den Bergh and Y.Englert</td>
+
                                        </tr>
+
                                        <tr>
+
                                          <td>Size of ZP2</td>
+
                                          <td>90–110 kDa</td>
+
                                          <td>Characterization of human zona pellucida glycoproteins A R Bauskin 1, D R Franken, U Eberspaecher, P Donner DOI: 10.1093/molehr/5.6.534</td>
+
                                        </tr>
+
                                        <tr>
+
                                          <td>Diameter of ZP2r</td>
+
                                          <td>0.0092 μm</td>
+
                                          <td>Zetasizer Nano Sensitivity Calculator (Classic)</td>
+
                                        </tr>
+
                                    </tbody>
+
                                 </table>
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                            </div>                           
+
                            <p>Assuming cuboid with all spheres of size same as ZP2 to
+
                            get volume of one unit = 3.1 e-6 μm3 </p>
+
                            <p>Volume occupied by whole ZP matrix = 12.4 e5 μm3 </p>
+
                            <p>Calculated the number of ZP2 glycoproteins present in the ZP matrix = 3.92 x 1011 molecules</p>
+
                            <p>Assuming 1 ovastacin cleaves 1 ZP2</p>
+
                            <p>No. of ovastacin = No. of ZP2 = 12.4 e5 / 3.1 e-6 = 3.92 x 1011  molecules ]</p>
+
                            <p>In order to cause complete hardening __ number of molecules are required to reach the ovum. The next question that arises is how much is produced and how much of produced ovastacin will reach the ovum. So we have two major things left to look at: </p>
+
                            <h5>2] Production and transport of ovastacin by GMO</h5> 
+
                            <p>The production of ovastacin is required for three days pre and post ovulation, please go to “Genetic Circuits” to learn details regarding the genetic circuit. </p> 
+
                            <h4>GENETIC CIRCUIT</h4>
+
                            <p>Progesterone repressible system</p>
+
                            <h4>JOURNEY OF OVASTACIN</h4>
+
                            <p>From the papers, we know that the ovum is propelled by the ciliary motion away from the uterus and that means the ovum is in contact with the wall. Thesize ampulla region of the Fallopian tube (2.5 mm ≤ radius ≤ 5 mm ) is much larger than the radius of the ovum (61.7μm) A molecule under the influence of Brownian motion move according to the equation</p>
+
                            <ul>
+
                                <li>< r <sup>2</sup> >= 4Dt (for 2-D)</li>
+
                                <li>< r <sup>2</sup> >= 6Dt (for 3-D)</li>
+
                                <p>Where,</p>
+
                                <li>< r <sup>2</sup>  > → mean squared (radial) distance travelled by the molecule</li>
+
                                <p>using,</p>
+
                                <ol>
+
                                    <li>k<sub>B</sub> = 1.38064852 ×10<sup>23</sup>  m<sup>2</sup> kg<sup>-2</sup> s<sup>-1</sup> K  [Boltzmann constant]</li>
+
                                    <li>η = 0.799 Pa·s [Viscosity of Oviductal Fluid]</li>
+
                                    <li>T = 35.5 + 273.15 = 308.65 K [Temperature of Oviduct]</li>
+
                                    <li>r = 22kDa = 2.43 nm [Radius of ovastacin molecule]</li>
+
                                    <li>a = 61.7 μm [Radius of the ovum]</li>
+
                                    <li>s = 5 mm [Radius of the ampulla region of the oviduct]</li>
+
                                    <li>N<sub>0</sub> = 3.92 ×10<sup>11</sup> molecules = 0.000650946529392 nanomoles [Number of ovastacin to react with all ZP2]</li>
+
                                     <p>
+
                                        For, Ovastacin D=1.1644194699 ×10<sup>-13</sup>  m<sup>2</sup> s<sup>-1</sup>
+
                                        </p>
+
                                 </ol>
+
                                <li>t → Time elapsed</li>
+
               
+
                            </ul>
+
 
                     </div>
 
                     </div>
                </div>
 
                <div class="card d-none d-md-block" style="max-width: 18rem;width: 25%; border: none !important;" id="index">
 
                    <div class="card-body">
 
                      <h5 class="card-title">INDEX</h5>
 
                      <h6 class="card-subtitle mb-2 text-muted">Card subtitle</h6>
 
                      <p class="card-text">Some quick example text to build on the card title and make up the bulk of the card's content.</p>
 
                      <a href="#" class="card-link">Card link</a>
 
                      <a href="#" class="card-link">Another link</a>
 
                      <ul>
 
                          <li><a href="#waste1">waste 1</a></li>
 
                          <li><a href="#waste2">waste 2</a></li>
 
                          <li><a href="#waste3">waste 3</a></li>
 
                          <li><a href="#waste4">waste 4</a></li>
 
                          <li><a href="#waste1">waste 1</a></li>
 
                          <li><a href="#waste2">waste 2</a></li>
 
                          <li><a href="#waste3">waste 3</a></li>
 
                          <li><a href="#waste4">waste 4</a></li>
 
                          <li><a href="#waste1">waste 1</a></li>
 
                          <li><a href="#waste2">waste 2</a></li>
 
                          <li><a href="#waste3">waste 3</a></li>
 
                          <li><a href="#waste4">waste 4</a></li>
 
                      </ul>
 
                    </div>
 
                  </div>
 
            </div>
 
        </main>
 
  
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                        <p id="1" class="pt-5 pb-md-3"></p>
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                        <h2>HOSTED COLLABS</h2>
  
 +
                        <h3>All India iGEM Meet 2021</h3>
  
 +
                        <p>The biggest collaboration of Indian iGEM teams, All India iGEM Meet 2021 was hosted from 23rd July 2021 to 25th July 2021 by the iGEM Teams of IISER Tirupati, IISER Thiruvananthapuram, IISER Bhopal, IISER Berhampur, IISER Pune, and MIT Mahe, and sponsored by Promega, India. Ten potential iGEM teams from India participated in several events organised by the members of the organising committee. The three-day event had a <strong>series of talks by experts in synthetic biology, project presentations by participating teams, workshops, fireside chat with Carlina Elizondo, Global Ambassador of iGEM</strong>, and many more fun-filled events. Our team hosted an insightful workshop on protein modeling, <strong>&lsquo;Proteios</strong>&rsquo; with our expert, <strong>Dr Madhusudhan M S</strong>, for all synthetic biology enthusiasts. During the presentation session, we had a pre-Giant Jamboree experience where the judges appreciated our idea, asked us questions regarding biosafety aspects of our project, and gave us some suggestions. We later went on to ponder upon the suggestions and answered them in our project efficiently. Our team had an amazing experience collaborating with the other iGEM teams throughout the span of a month to plan and conduct this event successfully.</p>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/9/9b/T--IISER-Tirupati_India--AIIM1.jpeg" alt="Poster of Proteios hosted during All India iGEM Meet" style="width:100%"><figcaption class="text-center my-1">All India iGEM Meet event, Proteios</figcaption>
 +
                        </figure>
 +
<br>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/a/a7/T--IISER-Tirupati_India--AIIM2.jpeg" alt="Presentation by team IISER-Tirupati_India at AIIM" style="width:100%"><figcaption class="text-center my-1">Presentation by team IISER-Tirupati_India at AIIM</figcaption>
 +
                        </figure>
  
 +
                        <h3>SynTrack: Podcast</h3>
 +
                        <p>In order to give a holistic view of synthetic biology to our audience, we started a podcast series and collaborated with various iGEM teams. This enabled us to cover a wide range of topics which involved three episodes on <strong>synthetic biology, its applications in iGEM and beyond, potential future in synthetic biology, and subsequent career opportunities in the field</strong>, especially for our young listeners. Followed by the episodes in collaboration with other iGEM teams across the globe. These episodes are uploaded on the iGEM server and to be released on <strong>Spotify by the name &ldquo;SynTrack&rdquo;</strong>.</p>
 +
                        <a class="text-primary" target="_blank" href="https://open.spotify.com/show/1ZGocNKdxmCReQbIuD3zVG?si=43fbd5d4fed74dfe" target="_blank">Link to Podcast(Spotify)</a>
 +
<br>
  
 +
                        <h4>Groningen:</h4>
 +
                        <p>Milou and Sofia of team Groningen brewed an informat-ious episode with Shubhra from team IISER Tirupati on applications of <strong>synthetic biology in the food industry</strong>, its pro&rsquo;s, cons, and future aspects.&nbsp;</p>
  
 +
                        <h4>Friendzymes:&nbsp;</h4>
 +
                        <p>Ahmed, Harini, and Giovanna of team Friendzymes had a fun time recording this podcast with Shubhra of team IISER Tirupati. They discussed <strong>democratizing biotechnology and the societal impact of synthetic biology</strong>.</p>
 +
                        <h4>IOANNINA:&nbsp;</h4>
 +
                        <p>Konstantinos from team IOANNINA and Shreyas from team IISER Tirupati had a dialogue on one of the most important aspects of synthetic biology that is <strong>safety</strong>. This collaborative episode cautiously transports the listeners to understand biosafety, kill switches, and their importance in synthetic biology.&nbsp;</p>
  
 +
                        <h4>FCB-UANL:&nbsp;</h4>
 +
                        <p>Cynthia and Leonardo from team FCB-UANL had a gala time discussing the <strong>importance of entrepreneurship and science communication in synthetic biology</strong> with Niloufer from team IISER Tirupati.</p>
  
 +
                        <h4>TU_Delft:</h4>
 +
                        <p>Milou from team TU_Delft had been constantly in touch with Shreyas from team IISER Tirupati to record this episode which deals with an extremely significant topic of <strong>Comprehensive Sexuality Education (CSE) and how different is the situation of imparting CSE in Netherlands and India to the general public</strong>. This episode had a topic which we all were looking forward to bringing to our listeners; however, due to unforeseen circumstances during this pandemic, this episode shall be released later.</p>
  
         <section class="container-fluid" style="background-color: rgb(245, 245, 245);">         
+
 
 +
                        <h3>Gene Gala</h3>
 +
                        <p>Gene Gala, a mini-summer school for high school girls, was envisioned in collaboration with <strong>Team IISER Kolkata</strong> to encourage high school students, especially <strong>girls to build a career in STEM</strong>. We collaborated on this summer school and with the help of the <strong>Directorate of Education, GNCT Delhi</strong>, who also believed in our views that to increase the participation of women in STEM fields we need to begin early. The team members of IISER Tirupati and IISER Kolkata met several times to brainstorm the structure of the program, prepared the presentation slides, and then conducted classes during the summer school together.<span id="2"></span> We enjoyed the participation of around <strong>50-55 students each day over the course of 5 days</strong>. We were glad to receive a heartwarming response from the students as well as the teachers and we felt delighted that we could change the student&rsquo;s minds who initially thought biotechnology was too difficult to handle.</p>
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                                <img src="https://static.igem.org/mediawiki/2021/2/2d/T--IISER-Tirupati_India--gene_gala_1.png" class="d-block w-100" alt="Gene Gala screenshot1">
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                              </div>
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                              <div class="carousel-item" data-bs-interval="4000">
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                                <img src="https://static.igem.org/mediawiki/2021/1/1b/T--IISER-Tirupati_India--gene_gala_2.png" class="d-block w-100" alt="Gene Gala screenshot2">
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                                <img src="https://static.igem.org/mediawiki/2021/5/5e/T--IISER-Tirupati_India--Gene_Gala3.png" class="d-block w-100" alt="Gene Gala screenshot3">
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                              </div>
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                              <div class="carousel-item" data-bs-interval="4000">
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                                <img src="https://static.igem.org/mediawiki/2021/f/f4/T--IISER-Tirupati_India--Gene_Gala4.png" class="d-block w-100" alt="Gene Gala screenshot4">
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                              </div>
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                            </div>
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<figcaption class="text-center my-3">Gene Gala</figcaption>
 +
                        <h2>INDIVIDUAL COLLABS</h2>
 +
                        <h3>iGEM IISER Thiruvananthapuram&nbsp;</h3>
 +
 
 +
                        <p>Our journey with IISER Thiruvananthapuram began back in the month of May when we brainstormed potential ideas for collaboration and came up with an idea to make a handbook for students in STEM and future iGEM teams. The goal of this handbook was to <strong>simplify and compile laws (national and international) relevant to synthetic biology</strong> and identify the gaps and loopholes in these laws. The amount of effort put into creating this handbook over the course of this iGEM season was extraordinary and the amount of knowledge gained by both teams during this process made us realise the importance of legislation and administrative bodies in science.</p>
 +
                        <p>We hope that this collaboration would also help future iGEM teams to gain an insight into their projects from a different perspective. (See <a href="https://2021.igem.org/Team:IISER-Tirupati_India/Contribution" target="_blank" style="color:blue;">Contribution)</a></p>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/5/52/T--IISER-Tirupati_India--IISER_TVM.jpeg" alt="Screenshot of our meet with iGEM IISER Thiruvanathapuram" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM IISER Thiruvananthapuram</figcaption>
 +
                        </figure>
 +
 
 +
                        <h3>iGEM Manchester</h3>
 +
                        <p>Although our project, OviCloak, serves an entirely different purpose than Team Manchester&rsquo;s project, UriGel, both teams realised that both teams shared a similar approach for delivery of our genetically engineered bacteria.</p>
 +
                        <p>We realised that in modern society, people are still skeptical about using catheters and hysteroscopes for any medical procedure because they&rsquo;re considered invasive. We discussed in length how both the teams&rsquo; human practices and outreach can help <strong>de-stigmatize and spread correct information</strong>.</p>
 +
                        <figure class="col-12 col-md-8 p-5 m-auto">
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                            <img src="https://static.igem.org/mediawiki/2021/2/2f/T--IISER-Tirupati_India--iGEM_Manchester.jpeg" alt="Collaboration with iGEM Manchester" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Manchester</figcaption>
 +
                        </figure>
 +
                        <h3>iGEM MSP - Meetings for Potential Partnership&nbsp;</h3>
 +
                        <p>iGEM MSP was one of the first few teams that we collaborated with over a couple of months. We spent initial meetings to discuss our project idea and brainstorm about potential collaboration opportunities.</p>
 +
                        <p>Both teams initially thought that due to certain similarities in our projects, we could share a kill switch module of our project with them. However, after deliberate and rigorous discussion, and exploring all possible options, we concluded that none of our team&rsquo;s designed kill switches were compatible with Team iGEM MSP&rsquo;s project.</p>
 +
                        <p>Nevertheless, they got some inspiration from our kill switches and we tried to help them by providing them references from our literature review.</p>
 +
                        <p>This could have been an amazing, long-term partnership nevertheless we collaborated for an <strong>International GMO survey</strong> with them and submitted an article for their journal, <strong> <a href="https://2021.igem.org/Team:MSP-Maastricht/Communication" >MSP-Vector</a></strong>.</p>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/5/55/T--IISER-Tirupati_India--iGEM_MSP.jpeg" alt="Collaboration meet with iGEM MSP" style="width:100%">                        </figure>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/9/94/T--IISER-Tirupati_India--iGEM_MSP2.jpeg" alt="Collaboration meet with iGEM MSP" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM MSP</figcaption>
 +
 
 +
                        </figure>
 +
 
 +
                        <h3>Late-night first collab meet - iGEM OSU</h3>
 +
                        <p>Taking the first step towards beginning the iGEM journey, Team iGEM OSU organised a global online meetup, open to all teams looking forward to participating in iGEM 2021. Since it was very early on in the competition, members from each team discussed different ideas and brainstormed together on various aspects of an iGEM project to find potential collaborations. It was a fun and eye-opening experience for us since this was our first meeting with any other iGEM team.</p>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/a/a4/T--IISER-Tirupati_India--Late_night_first_collab_meet_-_OSU.jpeg" alt="Collaboration meet with iGEM OSU" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM OSU</figcaption>
 +
                        </figure>
 +
 
 +
                        <h3>iGEM Go Paris</h3>
 +
                        <p>In a very short and sweet collaboration, with iGEM Go Paris, we discussed our project and appreciated the way both the projects used <strong>synthetic biology to tackle the issues related to the reproductive system</strong>. Their project was aimed towards <em>diagnosing and treating </em>Endometriosis, a painful condition which many times doesn&rsquo;t get diagnosed in time. We participated in the monument challenge organized by their team on social media, a fun activity to learn about different monuments of historical significance from a lot of places all over the world. <br /></p>
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                        <figure class="col-12 col-md-8  m-auto">
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                            <img src="https://static.igem.org/mediawiki/2021/6/69/T--IISER-Tirupati_India--iGEM_Go_Paris.jpeg" alt="Collaboration meet with iGEM Go Paris" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Go Paris</figcaption>
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 +
                        </figure>
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                        <figure class="col-12 col-md-8 m-auto">
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                            <img src="https://static.igem.org/mediawiki/2021/1/17/T--IISER-Tirupati_India--iGEM_Go_Paris2.jpeg" alt="iGEM Monument Challenge" style="width:100%"><figcaption class="text-center my-1">iGEM Monument Challenge</figcaption>
 +
                        </figure>
 +
                        <h3>iGEM Leiden</h3>
 +
 
 +
                        <p>Meeting with members of the iGEM 2021 team of Leiden who is around 7000 kilometers away, gave us a boost when we had a great conversation sharing each other&rsquo;s ideas to explore the concepts to <strong>ensure biosafety</strong> while engineering the chassis organism in both the projects.&nbsp;</p>   
 +
                        <figure class="col-12 col-md-8  m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/6/69/T--IISER-Tirupati_India--iGEM_Go_Paris.jpeg" alt="Collaboration meet with iGEM Leiden" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Leiden</figcaption></figure>
 +
                 
 +
<br>
 +
 
 +
<h3>iGEM Korea_HS</h3>
 +
                        <p>We were delighted to meet a high school iGEM team, Korea_HS during our collaboration meets. The team Kora_HS contacted us for collaboration and <strong>guidance for experiments and helping overcome the roadblocks</strong> in their iGEM journey. The first meeting was an engaging troubleshooting session for the problems faced by team Korea_HS and helped them understand the details behind several deliverables and requirements for iGEM. We were glad to discuss several other aspects of the project, including wet lab experiment design, dry lab, and human practices. In the follow-up meeting, we discussed their <strong>wet lab and protein modelling progress</strong> and suggested several possibilities to model their system. We had a great time helping a high school iGEM team during our iGEM journey and we were delighted with their results and we wished each other good luck for the Jamboree.&nbsp;</p>
 +
 
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/a/ac/T--IISER-Tirupati_India--Korea1.jpeg" alt="Screenshots of our meets with iGEM Korea HS1" style="width:100%">
 +
                        </figure>
 +
                        <figure class="col-12 col-md-8 p-5 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/f/fc/T--IISER-Tirupati_India--Korea2.jpeg" alt="Screenshot of our meet with iGEM Korea HS2" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Korea HS</figcaption>
 +
                        </figure>
 +
                        <h3>iGEM IISER Mohali&nbsp;</h3>
 +
 
 +
                        <p>We collaborated with the iGEM 2021 Team of IISER Mohali to discuss the protein modelling aspects of both teams. We <strong>helped the team troubleshoot hurdles they were facing</strong>. We exchanged our ideas to put forward new insights into methods, concepts, and tools for modelling their protein. <br />Team IISER Mohali helped us increase our reach and awareness on the importance of our project and the need for an alternative method of contraception through a <strong>monthly digital publication at IISER Mohali</strong>, <a target="_blank" href="https://manthanmagazine.wordpress.com/2021/10/03/ovicloak-a-novel-contraceptive-for-uterus-owners/">Manthan</a>. <br /><br /></p>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/1/16/T--IISER-Tirupati_India--IISER_Mohali_1.jpeg" alt="Collaboration meet with iGEM Team IISER Mohali" style="width:100%">
 +
                        </figure>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/f/f6/T--IISER-Tirupati_India--IISER_Mohali_2.jpeg" alt="Our article published in the manthan Magazine" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM IISER Mohali</figcaption>
 +
                        </figure>
 +
                        <p id="3" class="pt-5 pb-md-3"></p>
 +
                        <h2>GROUP COLLABS</h2>
 +
                        <h3>International GMO Survey - Team MSP, Team Aachen, Team IISER Pune, and Team IISER Tirupati</h3>
 +
                        <p>Team MSP brought forward this idea of <strong>collaboration in creating a standard survey</strong> to collect views of people across the globe keeping in mind the general opinion that people have <strong>regarding synthetic biology and genetically modified organisms</strong>. (See <a href="https://2021.igem.org/Team:IISER-Tirupati_India/Education" taget="_blank" style="color:blue;">Education</a> to view the survey details)</p>
 +
<figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/b/bc/T--IISER-Tirupati_India--International-GMO_Survery_Collaboration.jpeg" alt="iGEM IISER Tirupati in International GMO Survey" style="width:100%"><figcaption class="text-center my-1">iGEM IISER Tirupati in International GMO Survey</figcaption></figure>
 +
<br>
 +
 
 +
                        <h3>iGEM Patras: Rosalind Chronicles:</h3>
 +
                        <p>iGEM Patras along with iGEM Thessaloniki organised a photo collage geared towards <strong>honouring women in STEM</strong>. Every participating team had to send a group picture of all the women in their team along with a biography about a woman scientist from their country who inspires them. We wrote about our very dear <strong>Prof G Ambika, Professor, Department of Physics, IISER Tirupati, India, our secondary PI</strong>; who has inspired us along our iGEM journey and even beyond that as she creates a <strong>masterstroke with her touch in every aspect of science and arts</strong> that she explores. The host iGEM teams prepared a padlet bulletin board with all the women inspiring the participating teams along with the female members of those teams which is such an inspiring as well as empowering view for all science enthusiasts. <a target="_blank" href="https://padlet.com/louisjacquesruel/Rosalind_Chronicles">(Click here to view the website)</a></p>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/3/3d/T--IISER-Tirupati_India--Patras_Rosalind_Chronicles1.jpeg" alt="Our inspiration for Rosalind Chronicles Prof G Ambika" style="width:100%">
 +
                        </figure>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/8/84/T--IISER-Tirupati_India--our_teamgal.jpeg" alt="Our team photo with only women members four of them are wearing lab coats and three of them are present virtually through laptop screen held by Komal" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Patras and iGEM Thessaloniki for Rosalind Chronicles</figcaption>
 +
                        </figure>
 +
<br>
 +
 
 +
                        <h3>iGEM Stockholm&nbsp;</h3>
 +
                        <p>iGEM Stockholm hosted two meetings on Gathertown, Project reveal night and Project update meetup. We personally found it very interesting as iGEM Stockholm very creatively used an interactive platform like Gathertown. We were able to have great conversations about our projects, know what the other teams from around the world are upto.&nbsp;</p>
 +
                        <p>We also participated in their workshop &ldquo;<strong>From iGEM to entrepreneur&rdquo;, </strong>&nbsp;and learned lots of eye-opening aspects of entrepreneurship.&nbsp;</p>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/0/02/T--IISER-Tirupati_India--iGEM_Stockholm1.jpeg" alt="Collaboration meet with iGEM Stockholm" style="width:100%">
 +
                        </figure>
 +
                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/a/aa/T--IISER-Tirupati_India--iGEM_Stockholm_2.jpeg" alt="Collaboration meet with iGEM Stockholm" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Stockholm</figcaption>
 +
                        </figure>
 +
 
 +
                        <h3>iGEM for Beginners - iGEM Bolivia</h3>
 +
                        <p>The sweet and warm folks from iGEM Bolivia invited us for an interview for a handbook called <strong>&ldquo;iGEM for Beginners&rdquo</strong>; that they&rsquo;ve been working on with other iGEM teams as well. During the interview, Shreyas and Aslaha from team IISER Tirupati, joined team Bolivia and covered a lot of topics starting from how to arrange funds for iGEM registration to having extensive conversations about how our team is managing to work together, with all our bittersweet experiences.<br /></p>
 +
 
 +
                        <h3>iJET- TU Darmstadt&nbsp;</h3>
 +
                        <p>Team TU Darmstadt along with team Aachen arranged this exciting collaboration, where every participating team had to record a 6-10 seconds video with the members catching a paper plane with the iGEM logo on it in sequential order from left to right with a twist of magical <strong>transition with lab coats</strong>. We were thrilled to see the outcome. After team TU Darmstadt combined these videos, the plane flew all over the world connecting teams from different places bringing us closer and united in our iGEM journey.&nbsp;</p>
 +
 
 +
<br>
 +
                        <h3>iGEM Dusseldorf</h3>
 +
                        <p>An exceptional collaboration to bring together several teams and help them connect, the postcard collaboration has been the <strong>most unique souvenir</strong> that every participating iGEM team. The teams that participated in this collaboration designed a postcard explaining their respective projects. We used this opportunity with the help of <strong>exquisite line art and small vectors to express our project OviCloak</strong>. We were delighted when we received so many creative postcards sent by all the other participating teams which were kindly shipped by team Dusseldorf.&nbsp;</p>
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                        <figure class="col-12 col-md-8 m-auto">
 +
                            <img src="https://static.igem.org/mediawiki/2021/c/c5/T--IISER-Tirupati_India--Dusseldorf.jpeg" alt="Collaboration meet with iGEM Dusseldrof" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Dusseldrof</figcaption>
 +
                        </figure>
 +
 
 +
                        <h3>iGEM Nantes</h3>
 +
 
 +
                        <p>During the time of a global pandemic, we reflected the importance of online collaboration to bring iGEM teams across the world together. iGEM 2021 team of Nantes took a step forward with this collaborative video in which we could connect iGEMers worldwide in a short period of time, <strong>rejoicing the beginning of the iGEM journey</strong>.&nbsp;</p>
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                        <div class="col-12 col-md-8 col-lg-6 m-auto" >
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                            <video style="width: 100%" muted id="myVideo" controls >
 +
                                <source src="https://static.igem.org/mediawiki/2021/f/f3/T--IISER-Tirupati_India--Collaborative_video-iGEM_Nantes.mov" type="video/mp4" id ="myVideo">
 +
                            </video>
 +
                        </div> 
 +
<figcaption class="text-center my-1">Collaborative video with iGEM teams across the globe</figcaption>
 +
<br>
 +
 
 +
                        <h3>iGEM Tas Taipei Challenge Accepted!</h3>
 +
 
 +
                        <p>The Sustainable Development Goals (SDGs) address the urgent environmental, political, and economic challenges around the world. The iGEM 2021 team of TAS_Taipei took one step further by targeting SDG 17: &lsquo;Partnerships for the Goals&rsquo; by uniting iGEM teams to participate in a global challenge. The teams made tasks for one another to complete. This was followed by a conference with all participating teams to discuss how we have tackled the SDGs through our projects in iGEM 2021. This initiative fulfilled its goal of focusing on action on top of the promotion, where we truly introspective various aspects of our projects and discussed as a global iGEM community to work towards a sustainable future. In this collaboration, we majorly focused on two out of five SDGs that we are focusing on in our project which is <strong>Goal 4: Quality Education, and Goal 3: Good Health and Wellbeing, more specifically, the subgoals 4.5 and 3.7</strong>. The tasks given by our team for these two goals were completed by team <strong>ATG X iGEM and team Friendzymes</strong> respectively. The valuable inputs from these teams helped us refine the SDGs in our project.</p>
 +
 
 +
                        <figure class="col-12 col-md-8 m-auto">
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                            <img src="https://static.igem.org/mediawiki/2021/b/b6/T--IISER-Tirupati_India--Tas_Taipei_Challenge_Accepted.jpeg" alt="Challenge with iGEM Tas Taipei" style="width:100%">
 +
                        </figure><figcaption class="text-center my-1">Challenge with iGEM Tas Taipei</figcaption>
 +
<br>
 +
                        <h3>iGEM Thessaly (Microbes everywhere!)</h3>
 +
 
 +
                        <p>In the world of synthetic biology, microorganisms have blessed us with systems to engineer and produce our molecule of interest or perform our desired functions. Yet, we don&rsquo;t know the importance of microbiota. iGEM 2021 team of Thessaly took a step forward to highlight the humongous significance of these tiny creatures on the occasion of World Microbiome Day on 27th June through a collaborative video where several iGEM teams, including our team, explained how we are harnessing the microbes for the greater good.</p>
 +
                        <p>Together with Team Aalto-Helsinki, team Thessaly co-organized <strong>MicrobioCOSMOS on the 20th of August, in which several teams presented their project</strong>, interacted with other teams, and dived into the microworld together.</p>
 +
                        <figure class="col-12 col-md-8 m-auto">
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                            <img src="https://static.igem.org/mediawiki/2021/3/35/T--IISER-Tirupati_India--Thessaly_%28Team_Thessaly_Microbes_everywhere%21%291.jpeg" alt="Collaboration meet with iGEM Thessaly" style="width:100%">
 +
                        </figure>
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                        <figure class="col-12 col-md-8 m-auto">
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                            <img src="https://static.igem.org/mediawiki/2021/c/ca/T--IISER-Tirupati_India--Thessaly_%28Team_Thessaly_Microbes_everywhere%21%292.jpeg" alt="Collaboration meet with iGEM Thessaly" style="width:100%"><figcaption class="text-center my-1">Collaboration with iGEM Thessaly</figcaption>
 +
                        </figure>
 +
<br>
 +
 
 +
                        <h3>iGEM LMSU (Lomonosov Moscow State University), Russia - iGEM Fem Club</h3>
 +
 
 +
                        <p>&lsquo;Women in STEM&rsquo;, we come to the need to discuss this important topic in the 21st century because the current statistics show that sexism in science still exists. The iGEM 2021 team of LMSU took a stand to speak about this problem and invited the <strong>female members of other iGEM teams</strong> to share their viewpoints at the Fem club. We were grateful to participate in this collaborative discussion where we shared the problems faced by females interested in the science in our country and possible ways how we as iGEMers can help better the situation in the world.&nbsp;</p>
 +
                        <figure class="col-12 col-md-8 m-auto">
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                            <img src="https://static.igem.org/mediawiki/2021/5/5e/T--IISER-Tirupati_India--iGEM_LMSU_%28Lomonosov_Moscow_State_University%29%2C_Russia_-_iGEM_Femme_Club.jpeg" alt="Collaboration meet with iGEM LMSU" style="width:100%">
 +
                        <figcaption class="text-center my-1">Collaboration with iGEM LMSU</figcaption></figure>
 +
 
 +
<p class="mt-5">This journey of iGEM 2021 was <strong>extraordinary and wholesome</strong> due to all these <strong>cherishing collaborations with iGEM teams worldwide</strong>. The online platforms connected us more with the iGEM community amidst a pandemic which helped us carry forward the <strong>essense of synthetic biology</strong> to a greater mass of people.</p>
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<div class="col-2"><img class="img-fluid" src="https://static.igem.org/mediawiki/2021/0/0d/T--IISER-Tirupati_India--NEB.svg"></div>
 
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                             <div class="col-3"><img class="img-fluid" src="https://static.igem.org/mediawiki/2021/9/99/T--IISER-Tirupati_India--Twist.svg"></div>
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                             <div class="col-3"><img class="img-fluid" src="https://static.igem.org/mediawiki/2021/6/6b/T--IISER-Tirupati_India--Invideo.svg"></div>
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                             <div class="col-3"><img class="img-fluid" src="https://static.igem.org/mediawiki/2021/0/06/T--IISER-Tirupati_India--Benchling.svg"></div>
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                         </div>
 
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                     <div class="quick_link_heading text-center mt-5 mb-5">Quick Links</div>
 
                     <div class="quick_link_heading text-center mt-5 mb-5">Quick Links</div>
 
                     <div class="col m-1">
 
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                         <h6 class="quick_link_heading">PROJECT</h6>><br>
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                         <h6 class="quick_link_heading">PROJECT</h6><br>
 
                         <div class="d-flex flex-column">
 
                         <div class="d-flex flex-column">
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Description">DESCRIPTION</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Description">DESCRIPTION</a>
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Design">DESIGN</a>
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                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Blueprint">BLUEPRINT</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Engineering">ENGINEERING</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Engineering">ENGINEERING</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Background">BACKGROUND</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Background">BACKGROUND</a>
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                         <h6 class="quick_link_heading">WETLAB</h6>><br>
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                         <div class="d-flex flex-column">
 
                         <div class="d-flex flex-column">
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/ProofOfConcept">PROOF OF CONCEPT</a>
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                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Proof_Of_Concept">PROOF OF CONCEPT</a>
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Design">BLUEPRINT</a>
+
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Design">DESIGN</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Parts">PARTS</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Parts">PARTS</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Results">RESULTS</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Results">RESULTS</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Safety">SAFETY</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Safety">SAFETY</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Notebook">LAB NOTEBOOK</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Notebook">LAB NOTEBOOK</a>
 +
                            <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Excellence">EXCELLENCE</a>
 +
 
                         </div>
 
                         </div>
 
                     </div>
 
                     </div>
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                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Education">EDUCATION</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Education">EDUCATION</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Communication">COMMUNICATION</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Communication">COMMUNICATION</a>
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Inclusivity">INCLUSION</a>
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                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Inclusivity">INCLUSIVITY</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Sustainable">SUSTAINABLE DEVELOPMENT</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Sustainable">SUSTAINABLE DEVELOPMENT</a>
 
                         </div>
 
                         </div>
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                         <h6 class="quick_link_heading">DRYLAB</h6>><br>
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                         <h6 class="quick_link_heading">DRYLAB</h6><br>
 
                         <div class="d-flex flex-column">
 
                         <div class="d-flex flex-column">
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Model">MODEL</a>
 
                             <a class="quick_link" href="https://2021.igem.org/Team:IISER-Tirupati_India/Model">MODEL</a>

Latest revision as of 03:33, 17 December 2021


Ovi-Cloak

SCROLL

HOSTED COLLABS

All India iGEM Meet 2021

The biggest collaboration of Indian iGEM teams, All India iGEM Meet 2021 was hosted from 23rd July 2021 to 25th July 2021 by the iGEM Teams of IISER Tirupati, IISER Thiruvananthapuram, IISER Bhopal, IISER Berhampur, IISER Pune, and MIT Mahe, and sponsored by Promega, India. Ten potential iGEM teams from India participated in several events organised by the members of the organising committee. The three-day event had a series of talks by experts in synthetic biology, project presentations by participating teams, workshops, fireside chat with Carlina Elizondo, Global Ambassador of iGEM, and many more fun-filled events. Our team hosted an insightful workshop on protein modeling, ‘Proteios’ with our expert, Dr Madhusudhan M S, for all synthetic biology enthusiasts. During the presentation session, we had a pre-Giant Jamboree experience where the judges appreciated our idea, asked us questions regarding biosafety aspects of our project, and gave us some suggestions. We later went on to ponder upon the suggestions and answered them in our project efficiently. Our team had an amazing experience collaborating with the other iGEM teams throughout the span of a month to plan and conduct this event successfully.

Poster of Proteios hosted during All India iGEM Meet
All India iGEM Meet event, Proteios

Presentation by team IISER-Tirupati_India at AIIM
Presentation by team IISER-Tirupati_India at AIIM

SynTrack: Podcast

In order to give a holistic view of synthetic biology to our audience, we started a podcast series and collaborated with various iGEM teams. This enabled us to cover a wide range of topics which involved three episodes on synthetic biology, its applications in iGEM and beyond, potential future in synthetic biology, and subsequent career opportunities in the field, especially for our young listeners. Followed by the episodes in collaboration with other iGEM teams across the globe. These episodes are uploaded on the iGEM server and to be released on Spotify by the name “SynTrack”.

Link to Podcast(Spotify)

Groningen:

Milou and Sofia of team Groningen brewed an informat-ious episode with Shubhra from team IISER Tirupati on applications of synthetic biology in the food industry, its pro’s, cons, and future aspects. 

Friendzymes: 

Ahmed, Harini, and Giovanna of team Friendzymes had a fun time recording this podcast with Shubhra of team IISER Tirupati. They discussed democratizing biotechnology and the societal impact of synthetic biology.

IOANNINA: 

Konstantinos from team IOANNINA and Shreyas from team IISER Tirupati had a dialogue on one of the most important aspects of synthetic biology that is safety. This collaborative episode cautiously transports the listeners to understand biosafety, kill switches, and their importance in synthetic biology. 

FCB-UANL: 

Cynthia and Leonardo from team FCB-UANL had a gala time discussing the importance of entrepreneurship and science communication in synthetic biology with Niloufer from team IISER Tirupati.

TU_Delft:

Milou from team TU_Delft had been constantly in touch with Shreyas from team IISER Tirupati to record this episode which deals with an extremely significant topic of Comprehensive Sexuality Education (CSE) and how different is the situation of imparting CSE in Netherlands and India to the general public. This episode had a topic which we all were looking forward to bringing to our listeners; however, due to unforeseen circumstances during this pandemic, this episode shall be released later.

Gene Gala

Gene Gala, a mini-summer school for high school girls, was envisioned in collaboration with Team IISER Kolkata to encourage high school students, especially girls to build a career in STEM. We collaborated on this summer school and with the help of the Directorate of Education, GNCT Delhi, who also believed in our views that to increase the participation of women in STEM fields we need to begin early. The team members of IISER Tirupati and IISER Kolkata met several times to brainstorm the structure of the program, prepared the presentation slides, and then conducted classes during the summer school together. We enjoyed the participation of around 50-55 students each day over the course of 5 days. We were glad to receive a heartwarming response from the students as well as the teachers and we felt delighted that we could change the student’s minds who initially thought biotechnology was too difficult to handle.

Gene Gala

INDIVIDUAL COLLABS

iGEM IISER Thiruvananthapuram 

Our journey with IISER Thiruvananthapuram began back in the month of May when we brainstormed potential ideas for collaboration and came up with an idea to make a handbook for students in STEM and future iGEM teams. The goal of this handbook was to simplify and compile laws (national and international) relevant to synthetic biology and identify the gaps and loopholes in these laws. The amount of effort put into creating this handbook over the course of this iGEM season was extraordinary and the amount of knowledge gained by both teams during this process made us realise the importance of legislation and administrative bodies in science.

We hope that this collaboration would also help future iGEM teams to gain an insight into their projects from a different perspective. (See Contribution)

Screenshot of our meet with iGEM IISER Thiruvanathapuram
Collaboration with iGEM IISER Thiruvananthapuram

iGEM Manchester

Although our project, OviCloak, serves an entirely different purpose than Team Manchester’s project, UriGel, both teams realised that both teams shared a similar approach for delivery of our genetically engineered bacteria.

We realised that in modern society, people are still skeptical about using catheters and hysteroscopes for any medical procedure because they’re considered invasive. We discussed in length how both the teams’ human practices and outreach can help de-stigmatize and spread correct information.

Collaboration with iGEM Manchester
Collaboration with iGEM Manchester

iGEM MSP - Meetings for Potential Partnership 

iGEM MSP was one of the first few teams that we collaborated with over a couple of months. We spent initial meetings to discuss our project idea and brainstorm about potential collaboration opportunities.

Both teams initially thought that due to certain similarities in our projects, we could share a kill switch module of our project with them. However, after deliberate and rigorous discussion, and exploring all possible options, we concluded that none of our team’s designed kill switches were compatible with Team iGEM MSP’s project.

Nevertheless, they got some inspiration from our kill switches and we tried to help them by providing them references from our literature review.

This could have been an amazing, long-term partnership nevertheless we collaborated for an International GMO survey with them and submitted an article for their journal, MSP-Vector.

Collaboration meet with iGEM MSP
Collaboration meet with iGEM MSP
Collaboration with iGEM MSP

Late-night first collab meet - iGEM OSU

Taking the first step towards beginning the iGEM journey, Team iGEM OSU organised a global online meetup, open to all teams looking forward to participating in iGEM 2021. Since it was very early on in the competition, members from each team discussed different ideas and brainstormed together on various aspects of an iGEM project to find potential collaborations. It was a fun and eye-opening experience for us since this was our first meeting with any other iGEM team.

Collaboration meet with iGEM OSU
Collaboration with iGEM OSU

iGEM Go Paris

In a very short and sweet collaboration, with iGEM Go Paris, we discussed our project and appreciated the way both the projects used synthetic biology to tackle the issues related to the reproductive system. Their project was aimed towards diagnosing and treating Endometriosis, a painful condition which many times doesn’t get diagnosed in time. We participated in the monument challenge organized by their team on social media, a fun activity to learn about different monuments of historical significance from a lot of places all over the world.

Collaboration meet with iGEM Go Paris
Collaboration with iGEM Go Paris

iGEM Monument Challenge
iGEM Monument Challenge

iGEM Leiden

Meeting with members of the iGEM 2021 team of Leiden who is around 7000 kilometers away, gave us a boost when we had a great conversation sharing each other’s ideas to explore the concepts to ensure biosafety while engineering the chassis organism in both the projects. 

Collaboration meet with iGEM Leiden
Collaboration with iGEM Leiden

iGEM Korea_HS

We were delighted to meet a high school iGEM team, Korea_HS during our collaboration meets. The team Kora_HS contacted us for collaboration and guidance for experiments and helping overcome the roadblocks in their iGEM journey. The first meeting was an engaging troubleshooting session for the problems faced by team Korea_HS and helped them understand the details behind several deliverables and requirements for iGEM. We were glad to discuss several other aspects of the project, including wet lab experiment design, dry lab, and human practices. In the follow-up meeting, we discussed their wet lab and protein modelling progress and suggested several possibilities to model their system. We had a great time helping a high school iGEM team during our iGEM journey and we were delighted with their results and we wished each other good luck for the Jamboree. 

Screenshots of our meets with iGEM Korea HS1
Screenshot of our meet with iGEM Korea HS2
Collaboration with iGEM Korea HS

iGEM IISER Mohali 

We collaborated with the iGEM 2021 Team of IISER Mohali to discuss the protein modelling aspects of both teams. We helped the team troubleshoot hurdles they were facing. We exchanged our ideas to put forward new insights into methods, concepts, and tools for modelling their protein.
Team IISER Mohali helped us increase our reach and awareness on the importance of our project and the need for an alternative method of contraception through a monthly digital publication at IISER Mohali, Manthan.

Collaboration meet with iGEM Team IISER Mohali
Our article published in the manthan Magazine
Collaboration with iGEM IISER Mohali

GROUP COLLABS

International GMO Survey - Team MSP, Team Aachen, Team IISER Pune, and Team IISER Tirupati

Team MSP brought forward this idea of collaboration in creating a standard survey to collect views of people across the globe keeping in mind the general opinion that people have regarding synthetic biology and genetically modified organisms. (See Education to view the survey details)

iGEM IISER Tirupati in International GMO Survey
iGEM IISER Tirupati in International GMO Survey

iGEM Patras: Rosalind Chronicles:

iGEM Patras along with iGEM Thessaloniki organised a photo collage geared towards honouring women in STEM. Every participating team had to send a group picture of all the women in their team along with a biography about a woman scientist from their country who inspires them. We wrote about our very dear Prof G Ambika, Professor, Department of Physics, IISER Tirupati, India, our secondary PI; who has inspired us along our iGEM journey and even beyond that as she creates a masterstroke with her touch in every aspect of science and arts that she explores. The host iGEM teams prepared a padlet bulletin board with all the women inspiring the participating teams along with the female members of those teams which is such an inspiring as well as empowering view for all science enthusiasts. (Click here to view the website)

Our inspiration for Rosalind Chronicles Prof G Ambika
Our team photo with only women members four of them are wearing lab coats and three of them are present virtually through laptop screen held by Komal
Collaboration with iGEM Patras and iGEM Thessaloniki for Rosalind Chronicles

iGEM Stockholm 

iGEM Stockholm hosted two meetings on Gathertown, Project reveal night and Project update meetup. We personally found it very interesting as iGEM Stockholm very creatively used an interactive platform like Gathertown. We were able to have great conversations about our projects, know what the other teams from around the world are upto. 

We also participated in their workshop “From iGEM to entrepreneur”,  and learned lots of eye-opening aspects of entrepreneurship. 

Collaboration meet with iGEM Stockholm
Collaboration meet with iGEM Stockholm
Collaboration with iGEM Stockholm

iGEM for Beginners - iGEM Bolivia

The sweet and warm folks from iGEM Bolivia invited us for an interview for a handbook called “iGEM for Beginners&rdquo; that they’ve been working on with other iGEM teams as well. During the interview, Shreyas and Aslaha from team IISER Tirupati, joined team Bolivia and covered a lot of topics starting from how to arrange funds for iGEM registration to having extensive conversations about how our team is managing to work together, with all our bittersweet experiences.

iJET- TU Darmstadt 

Team TU Darmstadt along with team Aachen arranged this exciting collaboration, where every participating team had to record a 6-10 seconds video with the members catching a paper plane with the iGEM logo on it in sequential order from left to right with a twist of magical transition with lab coats. We were thrilled to see the outcome. After team TU Darmstadt combined these videos, the plane flew all over the world connecting teams from different places bringing us closer and united in our iGEM journey. 


iGEM Dusseldorf

An exceptional collaboration to bring together several teams and help them connect, the postcard collaboration has been the most unique souvenir that every participating iGEM team. The teams that participated in this collaboration designed a postcard explaining their respective projects. We used this opportunity with the help of exquisite line art and small vectors to express our project OviCloak. We were delighted when we received so many creative postcards sent by all the other participating teams which were kindly shipped by team Dusseldorf. 

Collaboration meet with iGEM Dusseldrof
Collaboration with iGEM Dusseldrof

iGEM Nantes

During the time of a global pandemic, we reflected the importance of online collaboration to bring iGEM teams across the world together. iGEM 2021 team of Nantes took a step forward with this collaborative video in which we could connect iGEMers worldwide in a short period of time, rejoicing the beginning of the iGEM journey

Collaborative video with iGEM teams across the globe

iGEM Tas Taipei Challenge Accepted!

The Sustainable Development Goals (SDGs) address the urgent environmental, political, and economic challenges around the world. The iGEM 2021 team of TAS_Taipei took one step further by targeting SDG 17: ‘Partnerships for the Goals’ by uniting iGEM teams to participate in a global challenge. The teams made tasks for one another to complete. This was followed by a conference with all participating teams to discuss how we have tackled the SDGs through our projects in iGEM 2021. This initiative fulfilled its goal of focusing on action on top of the promotion, where we truly introspective various aspects of our projects and discussed as a global iGEM community to work towards a sustainable future. In this collaboration, we majorly focused on two out of five SDGs that we are focusing on in our project which is Goal 4: Quality Education, and Goal 3: Good Health and Wellbeing, more specifically, the subgoals 4.5 and 3.7. The tasks given by our team for these two goals were completed by team ATG X iGEM and team Friendzymes respectively. The valuable inputs from these teams helped us refine the SDGs in our project.

Challenge with iGEM Tas Taipei
Challenge with iGEM Tas Taipei

iGEM Thessaly (Microbes everywhere!)

In the world of synthetic biology, microorganisms have blessed us with systems to engineer and produce our molecule of interest or perform our desired functions. Yet, we don’t know the importance of microbiota. iGEM 2021 team of Thessaly took a step forward to highlight the humongous significance of these tiny creatures on the occasion of World Microbiome Day on 27th June through a collaborative video where several iGEM teams, including our team, explained how we are harnessing the microbes for the greater good.

Together with Team Aalto-Helsinki, team Thessaly co-organized MicrobioCOSMOS on the 20th of August, in which several teams presented their project, interacted with other teams, and dived into the microworld together.

Collaboration meet with iGEM Thessaly
Collaboration meet with iGEM Thessaly
Collaboration with iGEM Thessaly

iGEM LMSU (Lomonosov Moscow State University), Russia - iGEM Fem Club

‘Women in STEM’, we come to the need to discuss this important topic in the 21st century because the current statistics show that sexism in science still exists. The iGEM 2021 team of LMSU took a stand to speak about this problem and invited the female members of other iGEM teams to share their viewpoints at the Fem club. We were grateful to participate in this collaborative discussion where we shared the problems faced by females interested in the science in our country and possible ways how we as iGEMers can help better the situation in the world. 

Collaboration meet with iGEM LMSU
Collaboration with iGEM LMSU

This journey of iGEM 2021 was extraordinary and wholesome due to all these cherishing collaborations with iGEM teams worldwide. The online platforms connected us more with the iGEM community amidst a pandemic which helped us carry forward the essense of synthetic biology to a greater mass of people.

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