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NYCU-Taipei 2021 Results

Our Presentation

Cardiovascular Diseases (CVDs)
are the top killer in the world!

17.9 million lives are taken from CVDs, accounting for about 30% of global deaths.

Cardiovascular Diseases are mainly caused by thrombus, also known as blood clots.

One of the cardiovascular diseases, deep vein thrombosis (DVT), occurs when one or more thrombus forms in a person’s deep veins.

So, what happens when a person has DVT?

Sometimes, there aren’t any symptoms...
However, most of the time, it causes

redness, swelling, tightness, and pain in one’s legs.

When matters deteriorate, deep vein thrombosis causes tissue necrosis, putting patients at risk of amputation.

Worsestill, deep vein thrombosis can develop fatal complications, especially pulmonary embolism (PE). This happens when the blood clots of one’s legs travel to the vessels of lungs through the blood flow, resulting in lung damage, organ failure, and even death.

DVT could happen to people of all ages, especially those under these conditions...

Maintaining the same posture for a long period (Bedridden; Standing or sitting for a long time during long-distance travel)

The elderly (people over 60)

After major operations or serious injuries

Patients with cardiovascular or blood diseases, or malignant tumors

Family history (Inherited blood clotting disorders)

Obesity

Smoking

and so on...

Who came into rescue?

Nattokinase is a serine protease derived from Japanese traditional food Natto. It is an effective substance that could break down blood clots, and it could serve as a deep vein thrombosis prevention supplement. As a natural supplement, Nattokinase barely has adverse effects compared to medicines used to treat deep vein thrombosis.

Here are our main approaches to

Detect, React, and Protect

deep vein thrombosis from happening...

Detect

We developed a home-aid test kit that could detect the d-dimer absorbance intensity in one’s saliva sample. The signal could be converted into d-dimer concentration and be collected with our app. The user’s thrombosis risk and recommended dosage of Nattokinase would be calculated and displayed on the app.

React & Protect

We designed a E. coli Nissle 1917 live biotherapeutic product (LBP) that could produce production-improved Nattokinase. The E. coli 's Nattokinase production could also be controlled with our remote light-inducible system. With a single tap on the screen, an infrared signal could be sent to the small intestine, received by the E. coli LBP, and the secretion of the Nattokinase could be regulated. The constant release of Nattokinase into the small intestine could be guaranteed.