iGEM Patras 2021

Redefining Medicine

We are an iGEM team who investigates how the ideal personalized treatment can be achieved.

Hero Image

A comprehensive workflow for the identification & functional characterization of PGx variants

Characterization of the impact of genomic variants, with targeted panel-based resequencing, on the activity of CYP2D6 and CYP2C19 enzymes responsible for the metabolism of a wide range of clinically used drugs.

  • Use of a portable NGS sequencer.
  • In vitro assays via site-directed mutagenesis in eukaryotic cells.
  • Determination of the potentially deleterious effect of the genomic variants.
  • Molecular simulation via Docking to confirm the potential deleterious effect.
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ADRs in Hospitalized Patients

Deaths Annually from ADRs


Pharmacogenes Encoding the CYP450

Key Components

Our project is one of the many real life examples that the applications of Synthetic Biology to humans are unlimited. In the following images you will find the most important parts of our project.

Wet Lab

Manipulating liquids, biological matter, and chemicals to analyze the functionality of the studied enzymes.

Dry Lab

Applied and computational analysis via the creation of computer-generated models and simulations.


Structural molecular biology and computer-assisted drug and protein interaction.

Human Practices

Improving Project PGasus by verifying the need to establish PGx in clinical practice and discussing its importance and applications.


Becoming partners with iGEM Thessaloniki helped us accelerate our projects generally.

Science Communication

Trying to build bridges to link science to society and including all parts of our community to make an impact that will last.

Diversity & Inclusion

Our mission is to make Project PGasus intelligible to everyone eliminating certain discriminations based on gender, socioeconomic status, and abilities.

Kids and Adolescents

Comic, board and online games are interesting ways to make kids and adolescents familiar with Synthetic Biology.

Women In STEM

Rosalind Chronicles collaboration inspired women to aim higher and excel in any field of science they put their minds into, no matter their gender.

Hearing Impaired People

Inserting sign language in our promotional and team presentation video is an innovative approach to achieve inclusivity.

Visually Impaired People

Translating our comic in Braille and including Audio Description in our site allows people with visual problems access to Synthetic Biology.