Difference between revisions of "Team:Vilnius-Lithuania"

 
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          <img alt="AmebyeLogo" src="https://static.igem.org/mediawiki/2021/b/b0/T--Vilnius-Lithuania--amebyeLogo.svg"/>      AmeBye   
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        <div id="loading-animation">
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        <div>Loading...
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    <div class="background">
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      <div class="landing-page-content">
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        <div class="logo-container">
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          <div class="logo">
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            <object data="https://static.igem.org/mediawiki/2021/b/b0/T--Vilnius-Lithuania--amebyeLogo.svg">
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            </object>
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            <h1>AmeBye
 +
            </h1>
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            <div>Make
 +
              <i>E. histolytica
 +
              </i> history
 +
            </div>
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            <div id="logo-animation">
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            </div>
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          </div>
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        </div>
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        <div class="problem-container">
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          <div class="ameba-container">
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            <div>
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              <p>                You might recognise this famous protozoan - an <b>ameba</b> - from biology textbooks.                Although it looks fair and harmless, don't get fooled: it can be really dangerous.                More precisely,  
 +
                <b><i>Entamoeba histolytica
 +
                </i></b> species cause a disease called <b>amebiasis</b>.             
 +
              </p>
 +
              <p>                When
 +
                <i>E. histolytica
 +
                </i> cyst enters the human body through contaminated water,               food or hands it turns into a
 +
                <b>trophozoite
 +
                </b> - metabolically active form.             
 +
              </p>
 +
            </div>
 +
            <object data="https://static.igem.org/mediawiki/2021/c/c8/T--Vilnius-Lithuania--ameba.png">
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            </object>
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          </div>
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          <h3>
 +
            <i>E. histolytica
 +
            </i> appears in two forms
 +
          </h3>
 +
          <div class="text-container">
 +
            <div>
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              <p>
 +
                <b>Cysts
 +
                </b> have no invasive tendencies. However, when passed in the feces to the environment,                they
 +
                <b>can infect others</b>. We are targeting this form along with non-invasive trophozoites with probiotics.             
 +
              </p>
 +
            </div>
 +
            <div>
 +
              <p>
 +
                <b>Trophozoites
 +
                </b> multiply in the intestinal lumen and produce cysts.                They
 +
                <b>invade
 +
                </b> intestinal
 +
                <b>mucosa
 +
                </b> and cause               
 +
                <b>systemic infection
 +
                </b> in some cases. We are targeting trophozoites with a                diagnostic tool.             
 +
              </p>
 +
            </div>
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          </div>
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        </div>
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        <div class="map-content-container">
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          <div class="map-container">
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            <div class="map">
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            </div>
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          </div>
 +
          <div>
 +
            <div class="text-container">
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              <h3>50 000 000
 +
              </h3>
 +
              <div>people infected every year
 +
              </div>
 +
            </div>
 +
            <div class="text-container">
 +
              <h3>100 000
 +
              </h3>
 +
              <div>deaths every year
 +
              </div>
 +
            </div>
 +
            <div class="text-container">
 +
              <h3>3rd
 +
              </h3>
 +
              <div>deadliest protist caused infection in the world
 +
              </div>
 +
            </div>
 +
          </div>
 +
        </div>
 +
        <div class="prevention-container">
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          <h2>Problem
 +
          </h2>
 +
          <h3>Prevention
 +
          </h3>
 +
          <div>
 +
            <div class="text-container">
 +
              <p>                About
 +
                <b>80 - 90 %
 +
                </b> of the infected
 +
                <b>face no symptoms but can transmit
 +
                </b>                the disease to other people, who might be more susceptible and face intricate complications.                Unfortunately, current infection prevention is
 +
                <b>unspecific</b>, based on good sanitation,                avoidance of contaminated food and hands. These reasons justify the demand for prevention tools.             
 +
              </p>
 +
            </div>
 +
            <div class="circles-container">
 +
            </div>
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            <div>
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              <div>
 +
                <svg viewbox="0 0 48 48">
 +
                  <circle cx="24" cy="24" fill="white" r="24">
 +
                  </circle>
 +
                </svg>                No infection             
 +
              </div>
 +
              <div>
 +
                <svg viewbox="0 0 48 48">
 +
                  <circle cx="24" cy="24" fill="#FCCEC0" r="24">
 +
                  </circle>
 +
                </svg>                Asymptomatic infection             
 +
              </div>
 +
              <div>
 +
                <svg viewbox="0 0 48 48">
 +
                  <circle cx="24" cy="24" fill="#DB846C" r="24">
 +
                  </circle>
 +
                </svg>                Symptomatic infection             
 +
              </div>
 +
            </div>
 +
          </div>
 +
        </div>
 +
        <div class="solution-container">
 +
          <div>
 +
            <div>
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              <h3>Diagnostics
 +
              </h3>
 +
              <p>                Currently, methods designed to diagnose amebiasis are
 +
                <b>ineffective
 +
                </b> or
 +
                <b>unavailable
 +
                </b>                in the regions where this infection is widespread. Localization of the infection in                the organism is essential to find a proper treatment strategy.             
 +
              </p>
 +
            </div>
 +
            <object data="https://static.igem.org/mediawiki/2021/1/1e/T--Vilnius-Lithuania--microscope.png">
 +
            </object>
 +
          </div>
 +
          <h2>Solution
 +
          </h2>
 +
          <div>
 +
            <object data="https://static.igem.org/mediawiki/2021/f/fa/T--Vilnius-Lithuania--probiotics.png">
 +
            </object>
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            <div>
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              <h3>Probiotics
 +
              </h3>
 +
              <p>                As a tool to prevent amebiasis, our team created the basis for
 +
                <b>probiotics
 +
                </b> capable of
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                <b>naringenin biosynthesis</b>.                Naringenin is a flavanone naturally present in plants. Experimental data showed it reduced
 +
                <i>Entamoeba histolytica
 +
                </i>                virulence. Our probiotics could be consumed by locals that are carriers of the infection and travelers to prevent the                spread of the disease to other countries.             
 +
              </p>
 +
            </div>
 +
          </div>
 +
          <div>
 +
            <object data="https://static.igem.org/mediawiki/2021/9/98/T--Vilnius-Lithuania--test.png">
 +
            </object>
 +
            <div>
 +
              <h3>Diagnostic test
 +
              </h3>
 +
              <p>                This year we created the basis for
 +
                <b>a rapid, low-cost, user-friendly,                specific diagnostic test
 +
                </b> for diagnosing invasive amebiasis from blood serum.                Our test is based on the interaction between
 +
                <b>aptamers
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                </b> and specific proteins                secreted by
 +
                <i>E. histolytica</i>, resulting in a color change reaction. The test                could be valuable not only for healthcare institutions but for in-home use as well.             
 +
              </p>
 +
            </div>
 +
          </div>
 +
          <div class="bottom-text">
 +
            <div>
 +
              <p>                By combining these two solutions -               
 +
                <b>probiotics
 +
                </b> and the
 +
                <b>diagnostic test
 +
                </b> -                we could weaken the vitality of this silent killer and halt                the spread of amebiasis hazard.             
 +
              </p>
 +
            </div>
 +
          </div>
 +
        </div>
 +
        <div class="useful-links-container">
 +
          <h2>Useful links
 +
          </h2>
 +
          <div>
 +
            <a href="https://2021.igem.org/Team:Vilnius-Lithuania/Description">
 +
              <object data="https://static.igem.org/mediawiki/2021/1/1d/T--Vilnius-Lithuania--links_description.svg">
 +
              </object>
 +
              <div>Description
 +
              </div>
 +
            </a>
 +
            <a href="https://2021.igem.org/Team:Vilnius-Lithuania/Design">
 +
              <object data="https://static.igem.org/mediawiki/2021/4/4f/T--Vilnius-Lithuania--links_design.svg">
 +
              </object>
 +
              <div>Design
 +
              </div>
 +
            </a>
 +
            <a href="https://2021.igem.org/Team:Vilnius-Lithuania/Parts">
 +
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 +
              </object>
 +
              <div>Parts
 +
              </div>
 +
            </a>
 +
            <a href="https://2021.igem.org/Team:Vilnius-Lithuania/Software">
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 +
              </object>
 +
              <div>Software
 +
              </div>
 +
            </a>
 +
            <a href="https://2021.igem.org/Team:Vilnius-Lithuania/Human_Practices">
 +
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              </object>
 +
              <div>Human practices
 +
              </div>
 +
            </a>
 +
          </div>
 +
        </div>
 +
      </div>
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        </div>
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Latest revision as of 10:41, 20 October 2021

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You might recognise this famous protozoan - an ameba - from biology textbooks. Although it looks fair and harmless, don't get fooled: it can be really dangerous. More precisely, Entamoeba histolytica species cause a disease called amebiasis.

When E. histolytica cyst enters the human body through contaminated water, food or hands it turns into a trophozoite - metabolically active form.

E. histolytica appears in two forms

Cysts have no invasive tendencies. However, when passed in the feces to the environment, they can infect others. We are targeting this form along with non-invasive trophozoites with probiotics.

Trophozoites multiply in the intestinal lumen and produce cysts. They invade intestinal mucosa and cause systemic infection in some cases. We are targeting trophozoites with a diagnostic tool.

50 000 000

people infected every year

100 000

deaths every year

3rd

deadliest protist caused infection in the world

Problem

Prevention

About 80 - 90 % of the infected face no symptoms but can transmit the disease to other people, who might be more susceptible and face intricate complications. Unfortunately, current infection prevention is unspecific, based on good sanitation, avoidance of contaminated food and hands. These reasons justify the demand for prevention tools.

No infection
Asymptomatic infection
Symptomatic infection

Diagnostics

Currently, methods designed to diagnose amebiasis are ineffective or unavailable in the regions where this infection is widespread. Localization of the infection in the organism is essential to find a proper treatment strategy.

Solution

Probiotics

As a tool to prevent amebiasis, our team created the basis for probiotics capable of naringenin biosynthesis. Naringenin is a flavanone naturally present in plants. Experimental data showed it reduced Entamoeba histolytica virulence. Our probiotics could be consumed by locals that are carriers of the infection and travelers to prevent the spread of the disease to other countries.

Diagnostic test

This year we created the basis for a rapid, low-cost, user-friendly, specific diagnostic test for diagnosing invasive amebiasis from blood serum. Our test is based on the interaction between aptamers and specific proteins secreted by E. histolytica, resulting in a color change reaction. The test could be valuable not only for healthcare institutions but for in-home use as well.

By combining these two solutions - probiotics and the diagnostic test - we could weaken the vitality of this silent killer and halt the spread of amebiasis hazard.

Useful links