Difference between revisions of "Team:CKWA-China"

 
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{{CKWA-China/header}}
 
{{CKWA-China/header}}
 
<html>
 
<html>
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<style>
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<!--Main Slider-->
 
<!--Main Slider-->
 
         <section class="main-slider">
 
         <section class="main-slider">
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                             data-param4="" data-param5="" data-param6="" data-param7="" data-param8="" data-param9=""
 
                             data-param4="" data-param5="" data-param6="" data-param7="" data-param8="" data-param9=""
 
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                             data-thumb="https://static.igem.org/mediawiki/2021/2/2f/T--CKWA-China--slide3.jpg" data-title="Slide Title"
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                             data-thumb="" data-title="Slide Title"
 
                             data-transition="parallaxvertical">
 
                             data-transition="parallaxvertical">
  
 
                             <img alt="" class="rev-slidebg" data-bgfit="cover" data-bgparallax="10"
 
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                                 src="https://static.igem.org/mediawiki/2021/c/c1/T--CKWA-China--slide1.jpg">
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                                 src="https://static.igem.org/mediawiki/2021/9/91/T--CKWA-China--home1.jpg">
  
 
                             <div class="tp-caption" data-paddingbottom="[0,0,0,0]" data-paddingleft="[0,0,0,0]"
 
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                                 data-y="['middle','middle','middle','middle']"
 
                                 data-y="['middle','middle','middle','middle']"
 
                                 data-frames='[{"from":"y:[100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
 
                                 data-frames='[{"from":"y:[100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
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                                 <h4>We Proudly Service</h4>
+
                                 <h4>LonEase--a Natural Protease</h4>
 
                             </div>
 
                             </div>
  
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                                 data-y="['middle','middle','middle','middle']"
 
                                 data-y="['middle','middle','middle','middle']"
 
                                 data-frames='[{"from":"y:[100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
 
                                 data-frames='[{"from":"y:[100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
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                                 <h2>These Metro Markets</h2>
+
                                 <h2>Suppress Cancer Recurrence </h2>
 
                             </div>
 
                             </div>
  
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                                 data-y="['middle','middle','middle','middle']"
 
                                 data-y="['middle','middle','middle','middle']"
 
                                 data-frames='[{"from":"y:[-100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
 
                                 data-frames='[{"from":"y:[-100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
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                                 <div class="text">Flooring is a family-owned and operated business. we have been
+
                                 <div class="text">2021iGEM ,CWKA-China is coming.</div>
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                                    installing floorssince 1992 and have installed flooring and Tilling</div>
+
 
                             </div>
 
                             </div>
 
                         </li>
 
                         </li>
  
 
                         <!-- Slide 2 -->
 
                         <!-- Slide 2 -->
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                        <li data-description="Slide Description" data-easein="default" data-easeout="default"
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                             data-fsmasterspeed="1500" data-fsslotamount="7" data-fstransition="fade"
 
                             data-fsmasterspeed="1500" data-fsslotamount="7" data-fstransition="fade"
 
                             data-hideafterloop="0" data-hideslideonmobile="off" data-index="rs-1682"
 
                             data-hideafterloop="0" data-hideslideonmobile="off" data-index="rs-1682"
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                                     installing floorssince 1992 and have installed flooring and Tilling</div>
 
                                     installing floorssince 1992 and have installed flooring and Tilling</div>
 
                             </div>
 
                             </div>
−
                         </li>
+
                         </li>  -->
  
−
                        <!-- Slide 3 -->
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                        <!-- Slide 3 -->
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                        <li data-description="Slide Description" data-easein="default" data-easeout="default"
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                      <!--    <li data-description="Slide Description" data-easein="default" data-easeout="default"
 
                             data-fsmasterspeed="1500" data-fsslotamount="7" data-fstransition="fade"
 
                             data-fsmasterspeed="1500" data-fsslotamount="7" data-fstransition="fade"
 
                             data-hideafterloop="0" data-hideslideonmobile="off" data-index="rs-1683"
 
                             data-hideafterloop="0" data-hideslideonmobile="off" data-index="rs-1683"
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                                     installing floorssince 1992 and have installed flooring and Tilling</div>
 
                                     installing floorssince 1992 and have installed flooring and Tilling</div>
 
                             </div>
 
                             </div>
−
                         </li>
+
                         </li>  -->
  
 
                         <!-- Slide 4 -->
 
                         <!-- Slide 4 -->
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                        <li data-description="Slide Description" data-easein="default" data-easeout="default"
+
                      <!--  <li data-description="Slide Description" data-easein="default" data-easeout="default"
 
                             data-fsmasterspeed="1500" data-fsslotamount="7" data-fstransition="fade"
 
                             data-fsmasterspeed="1500" data-fsslotamount="7" data-fstransition="fade"
 
                             data-hideafterloop="0" data-hideslideonmobile="off" data-index="rs-1684"
 
                             data-hideafterloop="0" data-hideslideonmobile="off" data-index="rs-1684"
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                                 data-y="['middle','middle','middle','middle']"
 
                                 data-y="['middle','middle','middle','middle']"
 
                                 data-frames='[{"from":"y:[100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
 
                                 data-frames='[{"from":"y:[100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
−
                                 <h4>We Proudly Service</h4>
+
                                 <h4>LonEase</h4>
 
                             </div>
 
                             </div>
  
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                                 data-y="['middle','middle','middle','middle']"
 
                                 data-y="['middle','middle','middle','middle']"
 
                                 data-frames='[{"from":"y:[-100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
 
                                 data-frames='[{"from":"y:[-100%];z:0;rX:0deg;rY:0;rZ:0;sX:1;sY:1;skX:0;skY:0;","mask":"x:0px;y:0px;s:inherit;e:inherit;","speed":1500,"to":"o:1;","delay":1000,"ease":"Power3.easeInOut"},{"delay":"wait","speed":1000,"to":"auto:auto;","mask":"x:0;y:0;s:inherit;e:inherit;","ease":"Power3.easeInOut"}]'>
−
                                 <div class="text">Flooring is a family-owned and operated business. we have been
+
                                 <div class="text">2021iGEM ,CWKA-China is coming.</div>
−
                                    installing floorssince 1992 and have installed flooring and Tilling</div>
+
 
                             </div>
 
                             </div>
−
                         </li>
+
                         </li> -->
  
 
                     </ul>
 
                     </ul>
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             <div class="auto-container">
 
             <div class="auto-container">
 
                 <div class="sec-title text-center">
 
                 <div class="sec-title text-center">
−
                     <span class="title">Sureloc</span>
+
                     <span class="title">LonEase</span>
−
                     <h2>Surely Locate Cancer</h2>
+
                     <h2>LonEase</h2>
 
                 </div>
 
                 </div>
 
                 <div class="row clearfix padding-b">
 
                 <div class="row clearfix padding-b">
 
                     <div class="inner-box">
 
                     <div class="inner-box">
 
                         <p class="text" style="text-indent:2em;">
 
                         <p class="text" style="text-indent:2em;">
−
                            Non-small cell lung carcinoma (NSCLC) is a common type of epithelial cancer, which is not
+
                          Recurrence of cancer after surgical treatment is a major problem facing mankind nowadays, and cancer recurrence is a great threat for cancer patients. For example, bladder cancer recurs in up to 24%-84% of patients 5 years after surgical resection, in which overexpression of C-MYC protein is associated with approximately 44%-69% of these cases. We have investigated that Lon protein from uropathogenic Escherichia coli (UPEC) can be effective enough to degrade C-MYC protein and thus inhibit the proliferation of cancer cells. We plan to produce highly active Lon protease from E. coli this year and use it to design a drug to improve the surgical prognosis of bladder cancer population with C-myc gene overexpression.
−
                            sensitive to chemotherapy or radiotherapy. To address this issue, our team developed a
+
−
                            therapy based on magneto-hyperthermia. We designed a vector that codes for magnetic protein
+
−
                            crystals (MPCs) through the use of a tumor-specific promoter. Liposomes with surface
+
−
                            PEG-GE11 modifications carrying MPC vectors will target NSCLC cells. Post transfection,
+
−
                            targeted tumor cells will express MPCs, which enable the binding of iron. Iron-loaded MPCs
+
−
                            will then respond to localized alternating magnetic fields and induce cell death. The active
+
−
                            targeting ligand, tumor-specific promoter, and localized alternating magnetic fields provide
+
−
                            triple targeting security. Currently, we completed the in vitro isolation and purification
+
−
                            of the MPCs with successful confirmation of their magnetism. The successive steps are to
+
−
                            control the MPCs’ size, add the internal targeting ligand, and experiment the targeting
+
−
                            capabilities in vivo.
+
 
                         </p>
 
                         </p>
 
                     </div>
 
                     </div>
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                 <div class="row clearfix">
 
                 <div class="row clearfix">
 
                     <!-- News Block -->
 
                     <!-- News Block -->
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                     <div class="news-block col-md-4 col-sm-6 col-xs-12">
+
                     <!--<div class="news-block col-md-4 col-sm-6 col-xs-12">
 
                         <div class="inner-box">
 
                         <div class="inner-box">
 
                             <div class="image-box">
 
                             <div class="image-box">
−
                                 <video class="gl_video" id="gl_video_2" src="video/mda-kc21c5bv2fig3ieu.mp4"
+
                                 <video class="gl_video" id="gl_video_2" src="https://static.igem.org/mediawiki/2021/b/bb/T--CKWA-China--sp1.mp4"
 
                                     controls="“ture”"></video>
 
                                     controls="“ture”"></video>
 
                             </div>
 
                             </div>
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                             </div>
 
                             </div>
 
                         </div>
 
                         </div>
−
                     </div>
+
                     </div>-->
  
 
                     <!-- News Block -->
 
                     <!-- News Block -->
−
                     <div class="news-block col-md-4 col-sm-6 col-xs-12">
+
                     <!--<div class="news-block col-md-4 col-sm-6 col-xs-12">
 
                         <div class="inner-box">
 
                         <div class="inner-box">
 
                             <div class="image-box">
 
                             <div class="image-box">
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                             </div>
 
                             </div>
 
                         </div>
 
                         </div>
−
                     </div>
+
                     </div>-->
  
 
                     <!-- News Block -->
 
                     <!-- News Block -->
−
                     <div class="news-block col-md-4 col-sm-6 col-xs-12">
+
                     <div class="news-block col-md-12 col-sm-12 col-xs-12">
 
                         <div class="inner-box">
 
                         <div class="inner-box">
 
                             <div class="image-box">
 
                             <div class="image-box">
−
                                 <video class="gl_video" id="gl_video_2" src="video/mda-kc21c5bv2fig3ieu.mp4"
+
                                 <video style="width:100%;height:570px;" class="gl_video" id="gl_video_2" src="https://static.igem.org/mediawiki/2021/b/bb/T--CKWA-China--sp1.mp4"
 
                                     controls="“ture”"></video>
 
                                     controls="“ture”"></video>
 
                             </div>
 
                             </div>
−
                             <div class="content-box">
+
                             <div class="content-box" style="text-align:center;">
−
                                 <h3>Here's the subject of the video</h3>
+
                                 <h3>Email:schooloffice@cy.kaiwenacademy.cn</h3>
−
                                 <div class="text">I could write some video notes here, a little bit more introduction.
+
                                 <div class="text"> School Office:010-83028199
 
                                 </div>
 
                                 </div>
 
                             </div>
 
                             </div>

Latest revision as of 07:57, 21 October 2021

  • LonEase--a Natural Protease

    Suppress Cancer Recurrence

    2021iGEM ,CWKA-China is coming.
LonEase

LonEase

Recurrence of cancer after surgical treatment is a major problem facing mankind nowadays, and cancer recurrence is a great threat for cancer patients. For example, bladder cancer recurs in up to 24%-84% of patients 5 years after surgical resection, in which overexpression of C-MYC protein is associated with approximately 44%-69% of these cases. We have investigated that Lon protein from uropathogenic Escherichia coli (UPEC) can be effective enough to degrade C-MYC protein and thus inhibit the proliferation of cancer cells. We plan to produce highly active Lon protease from E. coli this year and use it to design a drug to improve the surgical prognosis of bladder cancer population with C-myc gene overexpression.

Our Video

Promotional Video

Email:schooloffice@cy.kaiwenacademy.cn

School Office:010-83028199