Team:CKWA-China
-
LonEase--a Natural Protease
Suppress Cancer Recurrence
2021iGEM ,CWKA-China is coming.
LonEase
Recurrence of cancer after surgical treatment is a major problem facing mankind nowadays, and cancer recurrence is a great threat for cancer patients. For example, bladder cancer recurs in up to 24%-84% of patients 5 years after surgical resection, in which overexpression of C-MYC protein is associated with approximately 44%-69% of these cases. We have investigated that Lon protein from uropathogenic Escherichia coli (UPEC) can be effective enough to degrade C-MYC protein and thus inhibit the proliferation of cancer cells. We plan to produce highly active Lon protease from E. coli this year and use it to design a drug to improve the surgical prognosis of bladder cancer population with C-myc gene overexpression.